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This volume explores a core medieval myth, the tale of an Arthurian knight called Wigalois, and the ways it connects the Yiddish-speaking Jews and the German-speaking non-Jews of the Holy Roman Empire. The German Wigalois / Viduvilt adaptations grow from a multistage process: a German text adapted into Yiddish adapted into German, creating adaptations actively shaped by a minority culture within a majority culture. The Knight without Boundaries examines five key moments in the Wigalois / Viduvilt tradition that highlight transitions between narratological and meta-narratological patterns and audiences of different religious-cultural or lingual background.
Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction of biliverdin to bilirubin by biliverdin reductase. There is ample evidence for the pleiotropic functions of biliverdin reductase in cell signaling and regulation of gene expression. This enzyme plays a major role in glucose uptake and the stress response. Bilirubin has been shown to behave as a "double-edged sword". It can exert either cytotoxic or cytoprotective effects, depending on the blood and/or tissue concentration of its free fraction, the nature of the target cell or tissue, and the cellular redox state. Its antioxidant effect is the basis for the proposed cardioprotective effect of relatively low blood concentrations of bilirubin in humans with moderate hyperbilirubinemia. This Special Topic forum is intended to serve as a platform for updating information and presenting advances in basic and clinical research in the above and related subjects.
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the int...
The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the major component of the outer leaflet and covering nearly three-quarters of the total outer cell surface. All LPSs possess the same general chemical architecture independently of bacterial activity (pathogenic, symbiotic, commensal), ecological niche (human, animal, soil, plant, water), or growth conditions. Endotoxins are large amphiphilic molecules consisting of a hydrophilic polysaccharide compo...
Expanding upon the research elucidated by the first volume of this collection, Advanced Protocols in Oxidative Stress II presents thirty additional cutting-edge chapters focusing on novel techniques for detecting ROS/RNS, unique AOX technology and applications, gene expression and biostatistics for evaluating OS-derived experimental data. The international panel of authors also provide animal models and numerous studies concentrating on mitochondria during hypoxic conditions using advanced methods for pO2, peroxynitrate, reactive S-nitrosothiols, lipid peroxides, COX, and the mitochondrial membrane potential. Due to the dynamic nature of this topic, this book is the second of several volumes...
Includes music.
Title of the first 10 volumes of the series is Germans to America : lists of passengers arriving at U.S. ports 1850-1855.