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Epitranscriptomics: The Novel RNA Frontier
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to iden...
Reading in the Digital Age: Young Children’s Experiences with E-books
This edited book focuses on affordances and limitations of e-books for early language and literacy, features and design of e-books for early language and literacy, print versus e-books in early language and literacy development, and uses of and guidelines for how to use e-books in school and home literacy practices. Uniquely, this book includes critical reviews of diverse aspects of e-books (e.g., features) and e-book uses (e.g., independent reading) for early literacy as well as multiple examinations of e-books in home and school contexts using a variety of research methods and/or theoretical frames. The studies of children’s engagement with diverse types of e-books in different social co...
Stem Cells and Progenitor Cells in Ischemic Stroke - Fashion or Future?
Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due to severe side effects and a limited time window. As such, only a minority of patients receives this kind of therapy, showing a need for new and innovative treatment strategies. Although neuroprotective drugs have been shown to be beneficial in a variety of experimental stroke models, they ultimately failed in clinical trials. Consequently, recent scientific focus has been put on modulation of post-ischemic neuroregeneration, either via stimulation of endogenous neurogenesi...
Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier
Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.
Intraoperative Radiotherapy (IORT) – A New Frontier for Personalized Medicine as Adjuvant Treatment and Treatment of Locally Recurrent Advanced Malignancy
Intraoperative radiotherapy (IORT) is a treatment delivery technique with reports starting in the early 20th century. There are numerous advantages of IORT in oncology including delivery of a tumoricidal radiation dose in a single treatment, direct visualization of the treatment area of interest, decreasing dose to surrounding tissues, among others. In this series we focus on the clinical application, radiobiology and physics of IORT with an emphasis on the Intrabeam system. As medicine and health care continue to evolve the new frontier of personalized medicine must continue to rigorously evaluate and implement technologies that limit costs and provide meaningful therapeutic benefit.
Frontiers
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Frontiers Past and Future
"Abbott offers a fruitful new way to read science fiction, one that also greatly enriches our understanding of western history and its impact on our collective imagination. Detailing the overlap of science fiction and western fiction - especially relating to their mutual interest in and concerns about frontier expansionism - he reveals an unsuspected common ground that informs the writings of both camps." "Reviewing the work of many Hugo and Nebula Award winners, as well as drawing upon popular film and television series (like the Buck Rogers serials), Abbott's study journeys across the far reaches of science fiction's universe."
The Routledge International Handbook of Learning with Technology in Early Childhood
The Routledge International Handbook of Learning with Technology in Early Childhood focuses specifically on the most cutting-edge, innovative and international approaches in the study of children’s use of and learning with digital technologies. This edited volume is a comprehensive survey of methods in children’s technologies and contains a rich repertoire of studies from diverse fields and research, including both educational and developmental psychology, post-humanist literacy, applied linguistics, language and phenomenology and narrative approaches. For ease of reference, the Handbook's 28 chapters are divided into four thematic sections: introduction and opening reflections; studies ...
