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This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field. Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19). This book provides an unparalleled description of current practices to enhance readers’ knowledge and practice skills.
Haematopoietic stem cell transplantation was initiated in the early 1970’s by pioneers studying radiation-induced bone marrow damage and blood transfusion. Since that time there have been over one million transplants and over 34 million donors registered with the world marrow donor association. This special edition of Frontiers in Immunology highlights the research achievements which led to the curative therapy of haematopoietic stem cell transplantation (HSCT) but also reviews the ongoing complications such as graft versus host disease (GvHD) and infection caused by the procedure. Early animal and human studies are reviewed as well as those which led to the development of changes in trans...
The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, i...
Rédigé sous l'égide du Collège des Enseignants d'Immunologie (ASSIM), cet ouvrage présente l'intégralité du programme de DFGSM 2-3 en immunologie fondamentale et immunopathologie, et constitue le référentiel national. Grâce à un important travail de concertation pédagogique, les auteurs mettent à disposition des étudiants un manuel complet et synthétique qui s'articule en 2 parties : - Tissu lymphoïde et sanguin ; - Immunopathologie et immuno-intervention. Cette 2e édition, tout en couleurs, comporte 40 chapitres. Le contenu clair et didactique est étayé de nombreux tableaux, schémas originaux et encadrés pour aller plus loin dans les aspects cliniques, et l'apprentissag...
This series aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in Immunology research, with a focus on Alloimmunity and Transplantation. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This Topic includes technologies and up-to-date methods which help advance science. The contributions to this collection will undergo peer review. Novelty may vary, but the utility of a method or protocol must be evident. We welcome contributions covering all aspects of Alloimmunity and Transplantation. Submissions will be handled by the team of Topic Editors in the respective sections.