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The Role of TNF-TNFR2 Signal in Immunosuppressive Cells and its Therapeutic Implications
CD4+FoxP3+ regulatory T cells (Tregs) play an indispensable role in the maintenance of immune homeostasis and prevention of autoimmune diseases, and represent a major cellular mechanism of tumor immune evasion. Targeting of Tregs has great potential in the treatment of some major human diseases, including autoimmunity, transplant rejection, GvHD, and cancer, and are critical controllers of immunity to infectious pathogens. It is expected they will also be central to the control of allergic and inflammatory diseases. Understanding the biological pathways crucial for the regulation of Treg activity is a prerequisite for harnessing the immense therapeutic potential of Tregs. TNF is generally be...
We Have Roots Too
"Anecdotes, tidbits and documents to provide insight into the lives of members of the Peterson, Freeland, gardner, Snider, Hurt and many other families of Tennessee, Kentucky, Virginia and North Carolina in the 18th, 19th and 20th centuries. Also, data on the Arnold family of Texas, the Ochs family of Tennessee and New York, the Wilder family of Vermont, the Barr family of Pennsylvania, and many others."--Back cover.
The EBMT Handbook
This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field. Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19). This book provides an unparalleled description of current practices to enhance readers’ knowledge and practice skills.
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