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Carcinogenic Potency Database; Endocrine Disruptors
Papers include: supp. to the carcinogenic potency database (CPD): results of animal bioassays published in 1993 to 1994; supplemental plot of the CPD; workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels; an approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults; evaluating the effects of endocrine disruptors on endocrine function during development; and species, interindividual, and tissue specificity in endocrine signaling. Illustrated.
Carcinogens and Anticarcinogens in the Human Diet
Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens...
Principles of Toxicology
A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the...
Carcinogen
During the last decades, cancer diseases have increased all over the world. The low quality of food and strong pollution of environment are the main prerequisites for carcinogenesis. The main problem for scientists is to find strategy for prevention of cancer diseases. Therefore, the information about the models for studying carcinogenesis and mutagens which appear during cooking, environmental pollutants, and tests for specific detection of carcinogens is particularly important. The book "Carcinogen" is intended for biologists, researchers, students in medical sciences and professionals interested in associated areas.
The Use of Short- and Medium-term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluation
Lifetime assays for carcinogenicity in experimental animals, together with data on genetic and related effects on a variety of organisms, have long been the foundation for predictions of carcinogenic hazard to human beings. Recent scientific advances have provided new assays and novel test systems that are beginning to supplement, and in the future may even replace, the well-established tests that have been widely used for the last four decades. This publication reviews the evidence that justifies the use of lesions that precede histologically defined malignancy as endpoints to predict carcinogenicity. It evaluates the utility of non-mammalian species and of genetically engineered rodents as subjects for carcinogenicity tests and mutations in cancer-related genes in human and experimental animal tumours as 'footprints' of environmental carcinogens. It evaluates the use of established and novel assays for genetic toxicity in the prediction of carcinogenicity. Finally it formulates recommendations on the use of such data in the process of evaluation of carcinogenic hazards by the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
Report on Carcinogens (12th Ed. )
The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances (hereinafter referred to as "substances") that may pose a hazard to human health by virtue of their carcinogenicity. For each listed substance, the report contains a substance profile which provides information on (1) the listing status, (2) cancer studies in humans and animals, (3) studies of genotoxicity (ability to damage genes) and biologic mechanisms, (4) the potential for human exposure to these substances, and (5) Federalregulations to limit exposures. Eight substances have been added to this 12th ed. of the report, which now includes 240 listings. The industrial chemical formaldehyde and a botanical known as aristolochic acids are listed as known human carcinogens. Six other substances captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene are added as substances that are reasonably anticipated to be human carcinogens. Figures. This is a print on demand report.
