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Balancing Alloantigen-Induced Immune Responses and Anti-tumor Immunity in Transplantation
Transplantation, encompassing both hematopoietic stem cell and solid organ transplants, is a critical medical intervention for treating various life-threatening conditions. However, it is often complicated by alloantigen-induced immune activation, a response triggered by the donor’s immune system against recipient antigens and/or the recipient's immune system against donor antigens. This immune activation can arise from prior sensitization events such as blood transfusions, previous transplants, or fetal-maternal interactions. While alloantigen-induced immune responses can be beneficial, as seen in the Graft vs. Leukemia (GvL) or Graft vs. Tumor (GvT) effects, they can also lead to adverse...
Advances in Immunology
"The series which all immunologists need."--The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching"--Journal of Immunological Methods"A provocative and scholarly review of research"--Journal of the American Medical Association"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject"--The Lancet"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a ma...
Shattered Dreams, Sliding Doors
Tells the definitive story of Ireland's infamous 1982 World Cup qualification campaign, while painting a vivid picture of 1980s Ireland through the eyes of a young football fan. By Irish Daily Star writer Paul Little, author of the widely acclaimed In the Shadow of Benbulben: Dixie Dean at Sligo Rovers. Primarily written in the present tense to give a 'real-time' feel to events, this riveting book: Draws on meticulous research of Irish newspapers and TV to bring to life all eight of the Republic of Ireland's 1982 World Cup qualifying matches Discusses how Eoin Hand took over from John Giles as Ireland manager after the first qualifier in Cyprus Covers the build-up to games in detail, from th...
Dendritic Cells
The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological con...
Polyfunctional Cytokines
Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.
