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Malaria Methods and Protocols
The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of ...
Flow Cytometry, Part B
From the Reviews of the First Edition: "This is a good reference manual for multi-user facility faced with a wide variety of biological applications." - CYTOMETRY "Flow Cytometry includes an impressive array of methods applicable to chromosome analysis, plant biology, marine biology, fluorescence, insitu hybridization, and others. It succeeds in providing the reader with good insight into the power of the technology throughout biology." - KENNETH A. AULT, MAINE CYTOMETRY RESEARCH INSTITUTE, MAINE MEDICAL CENTER, IN CANCER CELLS Flow Cytometry, Second Edition provides a complete and comprehensive two-volume laboratory guide and reference for the use of the most current methods in flow cytomet...
Kin Recognition in Protists and Other Microbes
Kin Recognition in Protists and Other Microbes is the first volume dedicated entirely to the genetics, evolution and behavior of cells capable of discriminating and recognizing taxa (other species), clones (other cell lines) and kin (as per gradual genetic proximity). It covers the advent of microbial models in the field of kin recognition; the polymorphisms of green-beard genes in social amebas, yeast and soil bacteria; the potential that unicells have to learn phenotypic cues for recognition; the role of clonality and kinship in pathogenicity (dysentery, malaria, sleeping sickness and Chagas); the social and spatial structure of microbes and their biogeography; and the relevance of unicells’ cooperation, sociality and cheating for our understanding of the origins of multicellularity. Offering over 200 figures and diagrams, this work will appeal to a broad audience, including researchers in academia, postdoctoral fellows, graduate students and research undergraduates. Science writers and college educators will also find it informative and practical for teaching.
Malaria Parasites
The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.
Science
A weekly record of scientific progress.
Annual Review of Genetics
Publishes original critical reviews of the significant literature and current development in genetics.
Malaria Transmission Biology
The malaria parasite life cycle is complex and includes an obligatory developmental stage in its mosquito vector host. This transition from human-host to mosquito-host to human-host involves multiple developmental stages and divergent host tissues. Over the years, the research focus on the asexual stage parasites, which causes the symptoms of the disease, has transitioned towards a renewed focus on the transmission forms (or gametocytes), the only stages transmittable to the mosquito vector through ingestion of an infected blood meal. Analysis of sporozoite-liver interactions that result in the establishment of parasitic infection in the mammalian host has become an important research focus,...
Pathogenic Fungi
The past decade has witnessed a mushrooming of research in the area of medical mycology. San-Blas (Venezuela Institute of Scientific Investigation) and Calderone (Georgetown University) present recent work in the field. Papers on fungal dimorphism and pathogenicity focus on morphogenesis, the cell cycle, and the cell wall of human pathogens, while.
