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Breaking the cycle: attacking the malaria parasite in the liver
Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical dise...
Plant Natural Products for Human Health
Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resu...
Battling Malaria
Malaria is an infectious disease common to several parts of the world, including Africa, northern South America, and Asia. During their service in the military, U.S. active members may be sent to any part of the world, including parts of the world where Malaria is an issue. In Liberia in 2003, for example, there was a 28 percent attack rate in Marines who spent a short time ashore, and half of the 80 Marines affected needed to be evacuated to Germany. This was not only costly to the U.S. military but dangerous as well. To fight against this disease, there exists a Malaria Vaccine program in the U.S. military. However, there exists a variety of potential vaccine targets for the most severe an...
Navy Medicine
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From Genome to Therapy
This important and exciting work brings together a high-calibre group of experts to discuss the practical application of genomic information to the development of drugs. Recent technological advances have led to a rapid acceleration in our ability to gather genetic data. The complete genetic sequences are now known for several organisms and accelerated programmes are in place for sequencing many other genomes, including human. The speed with which complete sequencing can be accomplished will continue to increase as new technologies come online. In principle, the scope for developing new diagnostic techniques and drugs is now greater than at any time in human history, but the pathway from genetic information to usable drug is a long and complex one. This major book covers such subjects as the current state of the art in squencing technology, the applications of these new technologies to sequencing the genomes of various organisms, and the challenge of proteomics. Additional contributions deal with legal and ethical implications of the new uses of genetic data, and functional genomics from the point of view of the pharmaceutical industry.
Right of Passage
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A Documentary History of the Illawarra & South Coast Aborigines, 1770-1850
Compilation of primary sources in chronological order; includes notes on ritual, territorial groupings and myths; extracts from explorers journals; accounts of contact history and violent conflict; settlement of Illawarra region; Macquaries punitive expedition; trial of Seth Hawker; extracts from Dumont DUrvilles journal; battle of Fairy Meadow; Murramarang Massacre; blanket distribution lists includes listings of individual recipients; census data includes Maneroo and South Coast 1843-1848 and Berrima Cencus 1851; reminiscences of Alexander Berry; Milton and Ulladulla Benevolent Society; Aborigines Protection Board Reports; Roseby Park Reserve; Bomaderry Aboriginal Childrens Home; artists representations of Aborigines; various references to death and disease; economic activity including fishing; Bunan and initiation ceremonies; Aboriginal reminiscences; various vocabularies; archaeological reports bibliography; Appendices include; Index to Blanket Lists (1833-42) sorted by English and Aboriginal names.
