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Invasive Electrophysiology for Beginners
What lies behind IAP, IVP, AH, HV, and LAVA? How can a SVT be differentiated through stimulation maneuvers? How is the mapping of complex arrhythmias achieved? The techniques of invasive electrophysiology are rapidly evolving and becoming increasingly sophisticated. This book explains the essential fundamentals of the field in an understandable manner, richly illustrated and with many practical tips. It specifically targets beginners who are seeking an overview of all aspects of invasive electrophysiology and wish to understand the connections. From the Content Electrophysiological mechanisms of cardiac arrhythmias Energy sources for ablation and their mechanisms of action Setup, puncture techniques, 3D mapping systems Diagnosis and therapy of cardiac arrhythmias, including typical and atypical atrial flutter, atrial fibrillation, idiopathic PVCs, VT in ischemic and non-ischemic cardiomyopathy Management of complications Practical Plus: Numerous video contributions on individual arrhythmias, mapping techniques, and diagnostic maneuvers, as well as a glossary with the most important technical terms
Platelets, Haemostasis and Inflammation
The book depicts the various roles of platelets in a variety of cardio-metabolic diseases. Traditional and non-traditional platelet functions are described in detail in atherosclerosis, metabolic syndrome, diabetes, myocardial infarction, and other vascular pathologies. Particular focus is put on platelets as a link between haemostasis and inflammation contributing to both. Last but not least the books links the most recent advances in basic sciences with promising novel therapeutic applications and first results of clinical trials. The book is written for biomedical scientists in the sub disciplines vascular biology, biochemistry and immunology; and it as well will be of interest and value for academic physicians like cardiologists, hematologists, general internists and vascular surgeons.
Vascular Mechanobiology in Physiology and Disease
This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
Cardiac Regeneration
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Epigenetics in Cardiac Disease
This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
The hERG Cardiac Potassium Channel
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.
Atrial Fibrillation: Selection of Management Strategy and Evaluation of Outcomes
Atrial fibrillation (AF) is an increasing arrhythmia disease; its pathophysiology is the subject of many studies. Rate and rhythm control along with stroke prophylaxis are the cornerstones of AF therapy. With the recent evolution of techniques, AF ablation is becoming the first therapeutic option in many centres worldwide. Pulmonary vein isolation (PVI) for paroxysmal AF is now well established. Additional methods are now rising with non-PV trigger ablation: such as drivers, posterior wall isolation, epicardial ablation... Recognition of physiopathological signature for AF is the next challenge for all rythmologists. This will be achieved only by collecting different inputs such as imagery a...
Genetic Causes of Cardiac Disease
This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.
