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Cardiac Remodeling: New Insights in Physiological and Pathological Adaptations
The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.
CaMKII in Cardiac Health and Disease
The calcium-calmodulin dependent protein kinases (CaMKs) are a broadly expressed family of calcium-sensitive intracellular kinases, which are responsible for transducing cytosolic calcium signals into phosphorylation-based regulation of proteins and physiological functions. As the multifunctional member of the family, CaMKII has become the most prominent for its roles in the central nervous system and heart, where it controls a diverse range of calcium-dependent processes; from learning and memory at the neuronal synapse, to cellular growth and death in the myocardium. In the heart, CaMKII directly regulates many of the most important ion channels and calcium handling proteins, and controls ...
The ESC Textbook of Heart Failure
The ESC Textbook of Heart Failure is the latest addition to the European Society of Cardiology (ESC) publications portfolio and is fully supported by the European Heart Failure Association. The textbook brings together internationally renowned experts in the field of heart failure to present an up-to-date understanding of all aspects of this chronic condition that worsens with time. It is estimated that the worldwide population of patients suffering from heart failure is approximately 26 million. This clinically oriented work reflects contemporary European guidelines from the ESC and the European Heart Failure Association and summarizes the latest evidence from clinical trials. Made up of ei...
Eye-Away
Johannes, an overly-protected boy, obsessed with his sailor uncle's fabricated Indian lore, seeks to locate a sacred & forbidden cave where he might meet his ghostly heroes. His pal, Buddy, a welfare child, seeks a cave as hideaway from his dysfunctional family where he can wait for the moment to run away to a sympathetic aunt. They spend their summer trying to realize these goals.
The Disappearance
'Gripping, heart-wrenching and painfully real. An absolute triumph' Iona Grey What was hidden will be revealed... When Frances' best friend Bronwyn disappeared over twenty years ago, her body was never found. The mystery over what happened has cast a shadow over Frances' life ever since. Now, it's 1942 and bombs are raining down on Bath. In the chaos a little boy - Davy Noyle - goes missing. Frances was meant to be looking after him and she is tortured by guilt at his disappearance. Where has he gone, and could he possibly have survived? But bombs conceal, and they reveal - and as quiet falls and the dust settles, a body is disturbed from its hiding place. What happened all those years ago? ...
Camden new series
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Ernestine
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