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Is Insulin Resistance the Eminence Grise of Aging and Non-Communicable Chronic Diseases?
Metabolic syndrome (MetS) is a complex condition characterized by obesity, dyslipidemia, and hypertension, and is closely linked to inflammation. It serves as a significant predictor for the development of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). Incretin-based therapies, particularly those involving glucagon-like peptide-1 receptor (GLP-1R) agonists, have been well-established in the treatment of T2DM and offer cardio-renal protection. Recent advancements have expanded their role to include weight management in obese individuals, with notable approvals such as liraglutide and semagluti...
