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Vascular Development
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in t...
Developmental Aspects of the Lymphatic Vascular System
The book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.
The Islets of Langerhans
When new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a strong...
DJ-1/PARK7 Protein
This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.
The NMDA Receptors
This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochemical, and behavioral aspects, to highlight their distinctive regulatory properties, their functional significance, and their therapeutic potential in a number of diseases. A group of international experts discuss the development of NMDA receptors, their basic functions, and how they are implicated in a wide range of diseases including depression, psychosis, and pain.
Vascular Pharmacology: Cytoskeleton and Extracellular Matrix
Vascular Pharmacology: Cytoskeleton and Extracellular Matrix, Volume 81, contains the latest information on the vascular cytoskeleton and extracellular matrix that is presented with helpful illustrations and supporting references by prominent scientists and highly-recognized experts in the vascular field. Topics of interest in this new release include Pharmacology of the Vascular Cytoskeleton and Extracellular Matrix, The Dynamic Actin Cytoskeleton in Smooth Muscle, The Role of the Actin Cytoskeleton in the Regulation of Vascular Inflammation, The Smoothelin Family of Proteins and the Smooth Muscle Cell Contractile Apparatus, Smooth Muscle Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF, and more. - Presents a must-read book on the vascular cytoskeleton and extracellular matrix - Contains up-to-date information on the structure, function and development of the vascular cell cytoskeleton - Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the fields of the vascular cytoskeleton, extracellular matrix, mechanotransduction and vascular remodeling
Jahrbuch der Heinrich-Heine-Universität Düsseldorf 2007/2008
Das Jahrbuch der Heinrich-Heine-Universität Düsseldorf versteht sich als Forum für den wissenschaftlichen Dialog der Universität zu Zeitfragen, zu aktuellen Problemlagen und Herausforderungen von Wissenschaft und Gesellschaft, als Brücke der Vermittlung zwischen Forschung und Öffentlichkeit sowie als Gedächtnisort der Innovationen und des Fortschritts in Forschung und Lehre der Universität und als Speicher der wissenschafts- und hochschulpolitischen Entscheidungen für strukturelle Weichenstellungen mit Langzeitwirkung. Zielgruppe ist die an den Arbeitsergebnissen in Forschung und Lehre sowie an wissenschaftlichen Entscheidungen der Heinrich-Heine-Universität interessierte Öffentli...
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Science
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Metabolism of Human Diseases
This second edition of the highly successful textbook Metabolism of Human Diseases expands on the role of key molecules in the human body and how their defective metabolism leads to common human diseases. This textbook integrates concepts from biochemistry, physiology and pathophysiology to provide a comprehensive overview of organ- and tissue-specific metabolism and signaling pathways that contribute to human diseases. The chapters focus on the metabolic processes of the main organs in the human highlighting on many diseases that are frequently diagnosed, have high mortality rates, and are costly to treat. As metabolic research continues to unveil critical insights into physiology and patho...
