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The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders
Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracorti...
Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Towards Mechanism-based Treatments for Fragile X Syndrome
It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.
Staff Directory
Vols. for 1982/1983- include : University of Illinois at Chicago. Health Sciences Center. Staff directory.
Promoting the Emotional and Behavioral Success of Youths
Clinicians often have difficulty helping the parents of youth with emotional and behavioral difficulties and fail to recognize that often it is the youth’s cognitive and learning weaknesses that drive their maladaptive behaviors. This book aims to help clinicians further understand the roots of youth’s maladaptive behaviors. It also addresses the impact of youth’s varied cognitive abilities on their behaviors and problems with self-esteem, particularly in youth that do not meet the diagnostic criteria for a formal learning disability. While many clinicians view learning deficits as impairments in specific academic skills, these deficits go beyond varied learning abilities and often exp...
