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Zinc Metalloproteases In Health And Disease
The zinc metalloproteases are a diverse group of enzymes which are becoming increasingly important in a variety of biological systems. Their major function is to break down proteins. This text presents recent research results on the biochemistry and molecular biology of these enzymes.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Cell Surface Peptidases in Health and Disease
Cells bristle with a battery of surface enzymes, of which the peptidases form the largest and best studied group. These ectopeptidases play crucial roles in many diverse biological functions, including the termination of peptide signals in the nervous system and at peripheral sites. Some of their key physiological roles, such as those of angiotensin- and endothelin-converting enzymes in generating vasoconstrictive agents and endopeptidase-24.11 in activating natriuretic peptides, enkephalins and tachykinins, have made them prime targets for the pharmaceutical industry. Interest among immunologists and haematologists was aroused when several were shown to be identical to cell-surface markers (CD antigens) on human leukocytes. Virologists have been excited to find that some double as receptors for certain viruses.
A PEPTIDE PRODRUG STRATEGY FOR INCREASING ORAL BIOAVAILABILITY (PRODRUG).
A peptide prodrug strategy designed to target the intestinal peptide transporter to increase absorption and then to target the cytosolic prolidase as the prodrug converting enzyme to release the drug from the peptide prodrug inside the cell was studied.
The Astacins
None
Management of Digestive and Liver Disorders in Infants and Children
Hardbound. This text has been organized to provide the reader with a comprehensive coverage of the physiological and biochemical processes essential for the understanding of diseases affecting the different parts of the gastrointestinal tract. It describes novel and recent concepts in the pathophysiology and management of common gastrointestinal, pancreatic and liver disorders encountered in infants and young children. Each chapter presents a basic clinical approach to the problem including pertinent investigations for confirming the diagnosis and for discussing the most appropiate therapy. Commonly used drugs are listed while references cited are the more recent rather than the classic ones. A vast number of related subjects are covered, each subject being presented by experts in that particular field.The book is divided into five parts: Disorders of the Oesophagus and Stomach; The Small Intestine and Stomach; The Exocrine Pancreas; and The Liver.T
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
