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Ion Channels and Disease
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophys...
Life at the Extremes
Explores the limits of human survival and the physiological adaptations that enable us to exist under extreme conditions. The author reviews limits to human life underwater, at high altitudes, at high speeds, at micro levels, and at freezing and hot temperatures.
Pancreatic Beta Cell in Health and Disease
The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Physiology and Pathophysiology of the Islets of Langerhans
Proceedings of the First International Meeting of the Pancreatic Islet Study Group held in the Alicante, Spain, November 25-28 1994
Current Catalog
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ABC Proteins
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. - Phylogeny and Evoloution of ABC Transporters - Fundamental Aspects of the Mechanism of Action of ABC Transporters - Prokaryote ABC Transporters - Non-Mammalian Transporters - Multidrug Transporters - ABC Transporters, Physiological Roles and Human Disease - Full color throughout
The Spark of Life
'A wonderful book' Bill Bryson 'Ashcroft achieves the sort of rich simplicity most science writers can only dream about ... this book carries the eponymous spark of life' Sunday Telegraph From before birth to the last breath we draw, from consciousness to sexual attraction, fighting infection to the beating of our hearts, electricity is essential to everything we think and do. In The Spark of Life award-winning physiologist Frances Ashcroft reveals the secrets of ion channels, which produce the electrical signals in our cells. Can someone really die of fright? How do cocaine, LSD and morphine work? Why do chilli peppers taste hot? Ashcroft explains all this and more with wit and clarity. Any...
Voltage-Sensitive Ion Channels
The goal of this book is to explore the complexity of a microscopic bit of matter that exists in a myriad of copies within our bodies, the voltage-sensitive ion channel. We seek to investigate the way in which these macromolecules make it possible for the long fibers of our nerve and muscle cells to conduct impulses. These integral components of cell membranes are marvels of nature's evolutionary adaptation. To understand them we must probe the boundaries of physics and chemistry. Since function is intimately related to structure, we examine the molecular structure of channels, focusing on physical principles that govern all matter. With the application of genetic methods, our knowledge of i...
