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Transcriptomics in Health and Disease
After sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and...
Oncolytic Viruses - Genetically Engineering the Future of Cancer Therapy
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Tailoring NK Cell Receptor-Ligand Interactions: an Art in Evolution, 2nd Edition
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the un...
Immunology of Diabetes V
This volume an overview of current research in the field of immunology as it relates to diabetes. Topics covered include: autoantibody markers for type 1 diabetes; cellular immune markers for type 1 diabetes; animal models of type 1 diabetes; the pancreas in type 1 diabetes; genetics of type 1 diabetes; the role of toll-like receptors and innate immunity in type 1 diabetes; cell-based therapies for type 1 diabetes; environmental and mechanistic causes of type 1 diabetes; mechanisms of beta-cell death; role of the immune response in type 1 diabetes; and islet transplantation. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Thompson & Thompson Genética Médica
Atualizado para refletir as mais novas mudanças na genética, o livro Thompson & Thompson Genética Médica retorna como um dos melhores textos neste campo fascinante e em rápida evolução. Por integrar os princípios clássicos da genética humana à genética molecular moderna, esta obra utiliza uma variedade de ferramentas de aprendizagem para ajudá-lo a compreender uma ampla gama de doenças genéticas. • Aprofunde seu conhecimento por meio de gráficos atualizados, textos coloridos, ilustrações, diagramas e fotos clínicas de doenças genéticas. • Explore o conteúdo mais recente em genética, para manter-se atualizado sobre as últimas tendências no campo. • Tire proveito de uma seção de estudos de casos clínicos de página dupla, que demonstra e reforça os princípios gerais da herança da doença, a patogênese, o diagnóstico, o manejo, e o aconselhamento. • Aprimore suas habilidades de pensamento crítico e retenha melhor as informações. Cada capítulo termina com "problemas genéticos rápidos relacionados com o que acaba de ser revisado, com respostas fornecidas no final do livro.
Thymus Transcriptome and Cell Biology
This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance. The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function is associated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases. This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field.
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