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Designer Drugs
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The Case of the Frozen Addicts
In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly...
Protein Misfolding, Aggregation and Conformational Diseases
The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
California Cures!: How The California Stem Cell Program Is Fighting Your Incurable Disease!
'An engrossing read that is hard to put down and packed with insights blend history and the latest research with broader examination of stem cell potentials to change not only health conditions, but society as a whole. No collection covering stem cell advancements should be without this hard-hitting examination that uses California's results as a foundation for considering stem cell's special promises and powerful obstacles to success.'Midwestern Book ReviewThirteen years ago, America faced an epidemic of chronic disease: cancer, paralysis, blindness, arthritis, Alzheimer's disease, diabetes and more.But California voters said 'YES!' to a $3 billion stem cell research program: the awkwardly-...
The Memory Thief
FINALIST FOR THE 2022 PEN/E.O. WILSON LITERARY SCIENCE WRITING AWARD "Aguirre writes clearly, concisely, and often cinematically. The book succeeds in providing an accessible yet substantive look at memory science and offering glimpses of the often-challenging process of biomedical investigation.”—Science Sometimes, it’s not the discovery that’s hard – it’s convincing others that you’re right. The Memory Thief chronicles an investigation into a rare and devastating amnesia first identified in a cluster of fentanyl overdose survivors. When a handful of doctors embark on a quest to find out exactly what happened to these marginalized victims, they encounter indifference and skept...
Monoamine Oxidase Inhibitors in Neurological Diseases
Emphasizing the role of monoamine oxidase (MAO) in the etiology and pathogenesis of Parkinson's disease and Alzheimer's disease, this up-to-date reference describes the genetics, physiology, biochemistry, pharmacology, and clinical aspects of this very important class of enzymes. Details how the interaction between selegiline (deprenyl) and MAO may retard the progression of neurodegenerative disorders! Providing the latest theories on how selegiline operates, Monoamine Oxidase Inhibitors in Neurological Diseases presents fundamental information on MAO types A and B examines the distribution of MAO A and B in the normal human brain investigates the effects of disease and aging on MAO A and B analyzes a critical role for MAO in the toxic action in Parkinson's disease elucidates selegiline's novel ability to delay the progression or repair the damage of dopaminergic neurons discusses the usefulness of MAO inhibitors in psychiatric disease and more!
