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Bacterial Endotoxic Lipopolysaccharides
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Cytokines in Severe Sepsis and Septic Shock
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tec...
Vaccines
The word “vaccine” derives from the Latin word for cow. The English physician, Edward Jenner, coined it in his 1798 pamphlet An Inquiry into the Causes and Effects of the Variolae Vaccinae. The last two Latin words mean “Smallpox of the Cow,” or cowpox. Jenner postulated that cowpox causes mild disease in humans while protecting them from the more dangerous smallpox. His proposal for inoculation with a weak form of disease-causing matter to prevent serious illness became the central concept of infectious disease medicine and has remained so ever since. The word “vaccine” was subsequently applied to immunizations against all infectious diseases. Its etymology is amazingly apt, bec...
Cytokines and Chemokines in Infectious Diseases Handbook
A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
Translational Medicine
Dieses Referenzwerk bietet einen vollständigen Überblick über die verschiedenen Phasen der Wirkstoffentwicklung und greift dabei auf einen translationalen Ansatz zurück.
Sepsis and Non-infectious Systemic Inflammation
Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.
