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Provides an introduction to modern object-oriented design principles and applications for the fast-growing area of modeling and simulation Covers the topic of multi-domain system modeling and design with applications that have components from several areas Serves as a reference for the Modelica language as well as a comprehensive overview of application model libraries for a number of application domains
Fritzson covers the Modelica language in impressive depth from the basic concepts such as cyber-physical, equation-base, object-oriented, system, model, and simulation, while also incorporating over a hundred exercises and their solutions for a tutorial, easy-to-read experience. The only book with complete Modelica 3.3 coverage Over one hundred exercises and solutions Examines basic concepts such as cyber-physical, equation-based, object-oriented, system, model, and simulation
In the past decades, advanced quantitative indexes obtained by cardiovascular magnetic resonance imaging (CMRI), such as myocardial strain, myocardial T1/ECV/T2/T2* relaxation value, myocardial blood flow quantification index and hemodynamics indexes, have been proposed as an alternative for non-invasive quantitative evaluation in various cardiovascular diseases. Those quantitative indexes have been proven to be more sensitive in assessing the early change of myocardial tissue, ventricular function, or hemodynamics, compared to the conventional qualitative methods. However, there are many challenges in the accurate measurement of those indexes as well as the evaluation of their clinical sign...
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same di...
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