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Current Issues and Future Direction in Kidney Transplantation
The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.
Maximising potential in organ donation and transplantation: transferrable paradigms
In this Special Issue, we present a conceptual framework which provides a blueprint for the components of successful national organ donation and transplant programs, and can be used for their assessment. Applying this framework, we then present a series of country case studies that highlight the distinctive features that have contributed to the success of the organ donation and transplant programs of Croatia, Italy, Portugal, Spain, and the United Kingdom and elaborate on the lessons that can be learned from them. We also apply this framework to analyse the Greek system, a comparatively weaker performer, and make recommendations for its reform and development. The framework and case studies ...
ESOT guidelines from the Transplantation Learning Journey 3.0
The Transplantation Learning Journey (TLJ 3.0) is the closing event of a one year leading international process, aimed at creating consensus among experts on burning transplant issues incompletely covered by scientific evidence. Through the TLJ 3.0 consensus platform, the European Society for Organ Transplantation (ESOT) demonstrates a strong commitment to providing clinical guidance based on rigorous evidence analysis and expert discussion within a methodologically sound and transparent process. This Special Issue compiles the guidelines from this process, which represents the first step of a continuous, regularly updated consensus program that ESOT envisions to shape future clinical pathways in increasingly complex transplant scenarios.
Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the tran...
Diversity, Equity, and Inclusion in Transplantation
Facing inequalities in transplantation – a call to improve access to care, outcomes and career developments. Following the call for action launched at the opening ceremony of the 2021 ESOT congress in Milan, and the mandate of the ESOT Action Day announced at the celebration of ESOT 40th anniversary on April 28, 2022, Transplant International is pleased to announce the launch of a Special issue on “Diversity, Equity, and Inclusion in Transplantation”. Gender disparities, minorities discriminations, barriers related to migration, limited access to healthcare because of low-income and deprived social networks, are still routinely embedded in current culture, systems, policies, and practi...
Oxford Textbook of Clinical Nephrology
Illustrated in full colour throughout, this comprehensive edition provides the reader with complete information on clinical and practical problems in nephrology.
Oxford Textbook of Clinical Nephrology
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and...
Clinical trial design and endpoints in kidney transplantation
In 2018, the European Society for Organ Transplantation (ESOT) initiated a Broad Scientific Advice request to the European Medicines Agency (EMA), to discuss their Committee for Medicinal Products for Human Use (CHMP) guidelines relating to the development of innovative therapies in the field of kidney transplantation. The request suggested several options for redefining endpoints used in clinical studies of kidney transplantation. It also proposed study design elements for stratification and subsequent employment of these novel proposals into future clinical trials. The proposed endpoints also aimed to be suitable for the conditional marketing authorization pathway. The EMA subsequently evaluated the discussion document and evidence provided by ESOT, issuing their final recommendations in December 2020. This Special Issue of Transplant International provides a detailed summary of key aspects of the proposals and recommendations for definitions of endpoints for clinical trials of kidney transplantation.
Current Issues and Future Direction in Kidney Transplantation
The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.
