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Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sc...
Reelin-Related Neurological Disorders and Animal Models
The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at...
Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Italians to America: March 1903-April 1903
Italians to America is the first indexed reference work devoted to Italian immigrants to the United States. This series contains passenger list information in chronological order on the first major wave of Italian migration during the last two decades of the nineteenth century, as well as the beginning of the twentieth century. As with the highly regarded companion series on German immigrants, Italians to America presents the passenger lists in chronological order, including information on each person's age, sex, occupation, village of origin, and destination, plus the name of the ship, the port of embarkation, and the date of arrival. Each volume also contains an introduction on the history of Italian migration to the U.S. and a full name index, greatly simplifying the researcher's job.
