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Gap Junctions
This monograph contains research articles from the leading laboratories around the world on gap junctions, the intercellular channels that allow communication between neighbouring cells. It describes the latest results in gap junctions research, the structural and functional characterization of cell-cell channels, the assembly and degradation of gap junctions, the expression and function of gap junctions in different tissues, knockout studies of gap junction genes, the regulation of connexin gene expression, and the functions of gap junctions in development and cancer. Any laboratory interested in intercellular communications and gap junction research will find this monograph an indispensable source of information and reference.
Current Concepts in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Edited and written by internationally recognized authorities, Current Concepts in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D) presents important insights to all aspects of this unique disease and will serve as a valuable guide to help readers provide the best possible care for their patients. Discussion of ARVC/D by the experts includes: · Basic and clinical science. · Pathophysiology, molecular mechanisms, and genetic background. · The mechanisms of disease progression leading to a diversity of disease phenotypes. · Challenges in the clinical setting with respect to diagnosis, risk stratification, and therapy. “The editors…have enlisted as authors those who fi...
The Science Fiction of Defeat
This book is the first to examine a body of cultural artifacts from Spain that depict wars likely to erupt in the near or distant future. Beginning with the earliest examples of imaginary wars published in the late nineteenth century, it traces the evolution of the genre and its interplay with real conflicts up to the end of the Spanish Civil War. The Science Fiction of Defeat uncovers a vast array of stories that explore the role of emerging technologies in modern warfare, shifts in the geopolitical landscape, the impact of World War I, the place of colonialism, fears of invasion, the specter of communism and fascism, and anxieties over the collapse of civilization. The book situates these texts within their historical context, both domestic and international, compares them to their European counterparts, and addresses issues of readership and influence. It reveals distinctive traits such as persistent Anglophobia, the use of humor, enduring imperialist aspirations, and anxieties about modernization and the nation. Expanding beyond literature, the book also investigates popular theater, reportage, comics, and collectible trading cards.
Channelopathies in Heart Disease
This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.
Interplay of Connexins and Pannexins in Tissue Function and Disease
This book is a printed edition of the Special Issue "Interplay of Connexins and Pannexins in Tissue Function and Disease" that was published in IJMS
Gap Junctions: Molecular Basis of Cell Communication in Health and Disease
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular ...
