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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Respiratory physiology is a key clinical domain that directly affects patient care – a truth that is deftly demonstrated by the Guest Editors of this Monograph, the distinguished bioengineers Raffaele Dellacà and Andrea Aliverti. By integrating classical concepts with the latest advancements, the Guest Editors and authors provide a comprehensive overview of the field. The Monograph highlights cutting-edge diagnostic techniques and bridges the gap between basic physiology and clinical practice, offering insight into how physiological principles inform disease diagnosis and management. It also explores emerging challenges and research directions, including the impact of ageing, sex and the environment. Providing an accessible insight into the exciting world of physiology, this Monograph is a must for all clinicians, researchers and trainees in pulmonary medicine.
Respiratory care is undergoing a period of major change as it cautiously begins to embrace digital transformation. Catalysed by the need for remote consultation in the pandemic, time-honoured approaches to delivering care are now being challenged by technology-based initiatives. This Monograph deftly guides the reader through the potential benefits and pitfalls of such change, breaking the discussion down into three areas: technological opportunities and regulatory challenges ; social benefits, challenges and implications; exemplars of digital healthcare. Each chapter reviews contemporary literature and considers not ‘if’ but ‘how’ a digital respiratory future can provide optimal care. The result is an authoritative, balanced guide to developing digital respiratory health.
COPD remains a major cause of ill health, disability, healthcare costs and premature mortality. Scientists and clinicians across many countries have made great efforts to understand this important disease, and these have yielded positive results. This Monograph provides an up-to-date overview of what is happening in this exciting field, both at a basic and a clinical level. Beginning, crucially, with the patient’s perspective, the chapters that follow consider the best way to define COPD, changes in the disease’s incidence and prevalence, and offer new insights into the role of the microbiome in COPD, advances in imaging and treatment options, both pharmacological and non-pharmacological. Taken together, these chapters are an important contribution to the Monograph series and the COPD field in general.
Asthma is one of the most prevalent respiratory diseases, affecting ~8% of the world's population. Given the huge impact of the condition, and the vast amount of progress that has been made in the field in the last 10 years, a Monograph on the topic is now timely. Opening with a section on pathophysiology, then moving on to cover diagnosis and assessment, therapeutic approaches, comorbidities and special circumstances, this Monograph provides an up-to-date overview of the current understanding of asthma mechanisms and how to deliver care for people with asthma.
Presents evidence from medical journals that beliefs, thoughts, and feelings can cure the body and shows readers how to apply this knowledge in their own lives. -- provided by publisher.
Publisher's Note: There is a new edition of Harrison's Principles of Internal Medicine. The 21st edition contains the most timely and comprehensive updates from the world's top experts. MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as t...
Turn your inner voice from critic to coach As humans, we all have a special ability that is unique to our species: an inner voice. It helps us focus, achieve our goals and reflect on life’s most joyful moments. But it can also be our biggest enemy, chewing over painful emotions and replaying embarrassments, hijacking our thoughts to run amok with ‘chatter’. How does this source of wisdom turn into our biggest critic? And how can we take back control? These are the questions one of the world’s leading experts on the conscious mind set out to answer twenty years ago, when he started on an audacious mission — to study the conversations we have with ourselves. In this hugely anticipate...
In May 2023, WHO declared that COVID-19 was no longer a public health emergency of international concern. In 2024, COVID-19 certainly has not gone away, but we can now take a more reflective look at the pandemic. This issue of the ERS Monograph does just that, bringing together a truly international group of experts, as befits a global illness, to consider areas such as: long-term sequelae in airway disease, interstitial lung disease, and in the immunocompromised; therapeutics in the community, in hospital and in the intensive care unit; and the pathophysiology and management of long COVID. The Guest Editors also consider the impact of COVID-19 on clinical research and scientific publishing, as well as looking to the future, considering what can be learnt from the pandemic.