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Motor Circuits and Motor Symptoms in Dystonia: Translational Approaches from Animal Models to Patients
Dystonia is a motor disorder characterized by muscle contractions causing abnormal postures and/or movements, which are very disabling and painful in severe forms. Dystonia is sometimes the only symptom of the disease, but it is also present in combination with other motor dysfunctions in many neurological diseases, including Parkinson's disease and dyskinetic disorders. The possibilities of medical treatment still remain quite limited with side effects. The pathophysiologic mechanisms of dystonia concern aberrant communication within brain networks, particularly involving the basal ganglia, the sensorimotor cortex, and the cerebellum. Aberrant communication involves a combination of physiol...
Larsen's Human Embryology E-Book
Offering a well-organized, straightforward approach to a highly complex subject, Larsen's Human Embryology, 6th Edition, provides easy-to-read, comprehensive coverage of human embryonic development for today's students. It integrates anatomy and histology with cellular and molecular mechanisms, focusing on both normal development and congenital anomalies. Highly illustrated with superb drawings and photographs, it features a strong clinical focus based on the most up-to-date scientific discoveries and understanding.Contains new information on gene editing via CRISPr technology, organoids and the study of human disease, transcription factors and signaling pathways, and single cell sequencing....
Margaret Atwood and Social Justice
Margaret Atwood and Social Justice eventually presents a loose ideology evident in the author’s major works of prose fiction. It insists, however, that Atwood is a writer, not an ideologue, and that, therefore, this ideology evolves over her career, always secondary to her presenting stories and characters and, through them, ideas. Throughout her career, Atwood has been concerned about the social injustice experienced by women. After expressing concern for the plight of the environment in Surfacing and workers in Life Before Man, Atwood turned quite political in Bodily Harm and The Handmaid’s Tale, blending her concern for justice for women with criticism of present-day Third-World and f...
Alan Sillitoe
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Canadian Books in Print
Includes French-language titles published by predominantly English-language Canadian publishers.
Modern Crises and Traditional Strategies
The 1990s have seen a growing interest in the role of local ecological knowledge in the context of sustainable development, and particularly in providing a set of responses to which populations may resort in times of political, economic and environmental instability. The period 1996-2003 in island southeast Asia represents a critical test case for understanding how this might work. The key issues explored in this book are the creation, erosion and transmission of ecological knowledge, and hybridization between traditional and scientifically-based knowledge, amongst populations facing environmental stress (e.g. 1997 El Niño), political conflict and economic hazards. The book will also evaluate positive examples of how traditional knowledge has enabled local populations to cope with these kinds of insecurity.
