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"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require...
A comprehensive look at how the 'establishment' responded to the Italian student revolt of 1968. Using oral interviews, media analysis and archival evidence, the book explores the reactions of those who became the frequent targets of student protests - professors, police, activists' parents, the clergy, journalists, lawyers and auto workers.
Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. - Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology - Offers a wide range of perspectives for basic and translational research - Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Feminist cultural historian Lucia Chiavola Birnbaum caps her previous work with The Future has an Ancient Heart, a scholarly study of the transformative legacy of African origins and values of caring, sharing, healing, and vision carried by African migrants throughout the world. Birnbaum focuses on the long endurance of these values from the first human communities in south and central Africa, ones that Africans manifested in the region of the African mediterranean landmass that later separated Africa from Europe and Asia when the ice melted and waters rose. These migrants reached every continent and later became spiritual as well as geograpical migrations back to Africa, from ancient times ...
This research topic is the second volume in this series, Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation. Please see Volume I here.T cell responses are essential for protection against pathogens but can also be detrimental to the host. Therefore many overlapping mechanisms exist to prevent both the development of autoimmunity and excessive tissue damage during chronic infections.T cell differentiation and effector function are shaped by the integration of different signals from the environment. These signals are orchestrated through a variety of signaling receptors including the T cell receptor, activating (co-stimulatory molecules or cytokines), and inhibitory (checkpoin...
Includes entries for maps and atlases.
In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell de...
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