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Masters and Servants on the Cape Eastern Frontier, 1760-1803
A history of the conquest and servitude of the Khoisan in the Cape eastern frontier.
Myeloid cells in health and liver disease
Cells of the myeloid lineage display diverse roles and functions both in tissue homeostatic conditions and during the development of liver diseases. Hepatic myeloid cells such asKupffer cells exert immune surveillance while maintaining immune tolerance. This helps to prevent excessive immune stimulation upon encounter with gut-derived antigens from food and commensal microbes, or rapidly identifying and eliminating pathogens. Myeloid cells also exhibit a dual role by contributing to both the initiation and progression of liver diseases. During liver inflammation, myeloid cells secrete cytokines and chemokines that promote chemotaxis and tissue damage. Further down the process they can undergo reprogramming into pro-resolving, anti-inflammatory cells. In extremis, these can lead to loss of liver function and development of fibrosis and cirrhosis. Liver myeloid cells can also dictate the progress of hepatic malignancy by either promoting the infiltration and activation or suppressing the activities of effector and/or cytotoxic T cells.
Government Gazette
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Khoikhoi, Microhistory, and Colonial Characters at the Cape of Good Hope
Microhistory unlocked new avenues of historical investigation and methodologies and helped uncover the past of individuals, an event, or a small community. Reclamation of “lost histories” of individuals and colonized communities of colonial South Africa falls within this category. This study provides historical narratives of indigenous Khoikhoi of modest status absorbed into Cape colonial society as farm servants during the eighteenth and nineteenth centuries. Based on archival and other sources, the author illuminates the “everyday life” and “lived experience” of Khoikhoi characters in a unique way. The opening chapter recounts the love-loathe drama between a Khoikhoi woman, Gri...
The Cape Law Journal
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