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Once the capital of the five-hundred-year Chosŏn dynasty (1392–1897) and the Taehan Empire (1897–1910), the city of Seoul posed unique challenges to urban reform and modernization under Japanese colonial rule in the early twentieth century, constrained by the labyrinthian built environment of the old Korean capital. Colonial authorities attempted to employ a strategy of "erasure"—monumental Japanese architecture was, for instance, superimposed upon existing palace structures—to articulate to colonized Korean subjects the transition from the pre-modern to the modern, and the naturalization of colonial rule as inevitable historical change. Drawing from and analyzing a wide range of ma...
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of...
In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.