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The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.
Functional Plasticity and Genetic Variation
With recent advances of modern medicine more people reach the 'elderly age' around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.
Gut Microbiome and Behavior
Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications. - Contains the expertise of contributors in the field who discuss the gut microbiome and its effect on the brain and behavior - Defines the scope of the influence of the gut microbiome and the potential mechanisms and implications - Charts the way forward in this frontier area of research
Antioxidants and Second Messengers of Free Radicals
This book is a printed edition of the Special Issue "Antioxidants and Second Messengers of Free Radicals" that was published in Antioxidants
Pharmacology of 5-HT6 receptors, Part I
The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. - Written by expert researchers - Covers all published literature to date in the field of 5-HT6 receptors
Animal Models for Medications Screening to Treat Addiction
Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field. - Brings together information on the current state of medication development for drug addiction using animal models - Contains comprehensive descriptions of various models associated with many forms of drug addiction - Adds new information for translational research in the field of drug addiction
Plants of Life, Plants of Death
Pythagoras, the ancient Greek mathematician, did not himself eat fava beans in any form; in fact, he banned his followers from eating them. Cultural geographer Frederick Simoons disputes the contention that Pythagoras established that ban because he recognized the danger of favism, a disease that afflicts genetically-predisposed individuals who consume fava beans. Contradicting more deterministic explanations of history, Simoons argues that ritual considerations led to the Pythagorean ban. In his fascinating and thorough new study, Simoons examines plants associated with ritual purity, fertility, prosperity, and life, on the one hand, or with ritual impurity, sickness, ill fate, and death, o...
Preclinical and clinical issues in Alzheimer’s disease drug research and development
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend suppor...
