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Preterm birth affects over 15 million newborns worldwide each year and is the main contributor of neonatal mortality and morbidity. While neonatal survival following preterm birth continues to improve, this has not been matched by a decline in neurological outcome. There is still a high prevalence of motor problems, executive dysfunction, and cognitive impairment in infants born preterm. Improved neuroimaging has helped to describe different types of neonatal brain injuries in this population and has given a better understanding of underlying pathogenesis. However, therapies are still lacking and there is a great need to find novel strategies to improve injury and functional outcome.
The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefl...
The Chemistry of Lignin provides a critical review of the literature published from 1949 to 1958. This book provides information pertinent to the fundamental aspects of lignin chemistry. Organized into 27 chapters, this book begins with an overview of the derivatives that are prepared for the characterization of the mother substance. This text then examines the various kinds of lignin and biosynthetic lignin-like products, which have been characterized by their behavior toward oxidation with nitrobenzene and alkali. Other chapters consider the morphological distribution of lignin in the wood fiber and the place of origin of lignin precursors and of the lignification process. This book discusses as well the formation or biosynthesis of lignin in plants and reviews the structure, isolation, and biosynthesis of lignin. The final chapter deals with producing lignin by the action of enzymes. This book is a valuable resource for lignin chemists, scientists, research workers, and botanists.