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Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the...
Dubbed?some would say drubbed?the ?godfather behind creative nonfiction? by Vanity Fair, Lee Gutkind takes the opportunity of these essays, and the rich material of his own life, to define, defend, and further expand the genre he has done so much to shape. The result is an explosive and hilarious memoir of Gutkind?s colorful life as a motorcyclist, a medical insider, a sailor, a college professor, an over-aged insecure father, and a literary whipping boy. ø In Forever Fat Gutkind battles his weight, his ex-wives, his father, his rabbi, his psychiatrist, and his critics in a lifelong cross-country, cross-cultural search for stability and identity. And from Gutkind?s battles, the reader emerg...
LIFE Magazine is the treasured photographic magazine that chronicled the 20th Century. It now lives on at LIFE.com, the largest, most amazing collection of professional photography on the internet. Users can browse, search and view photos of today’s people and events. They have free access to share, print and post images for personal use.
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Vol. 52-53 include Wartime Warehousing Industry Conference, 1st-2d
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