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This volume emphasizes the comparative approach to under standing vertebrate renal function. I am convinced that this approach is of particular value in understanding both the details of renal function at the cellular and subcellular levels and the renal role in regulating fluid volumes and solute concentrations. My exposure to this approach first occurred during a student research experience in the laboratory of Wilbur H. Sawyer, who also provided an introduction to the works of Homer W. Smith and August Krogh. The importance of this approach was reinforced by doctoral and postdoctoral research in the laboratory of Bodil Schmidt-Nielsen. It has been confirmed through years of personal exper...
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This volume in the Comprehensive Toxicology series demonstrates how the use of extremely powerful molecular and cell biology techniques has stimulated the growth of toxicology as a scientific discipline. The field of toxicology has evolved from its earlier days of in vivo and descriptive studies to focusing on mechanisms. Frequently, mechanisms require an examination at the cellular and molecular level. Molecular toxicology has opened the door to comprehending the basic mechanisms of how toxicants show their effects. The volume is a comprehensive, integrated profile of the molecular effects of toxicants and the molecular mechanisms involved in producing cellular and tissue injury.