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The Pathogenic Yersiniae – Advances in the Understanding of Physiology and Virulence, Volume II
Pathogenic Yersinia consist of the prominent human pathogens Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis, the fish pathogen Y. ruckeri, as well as a number of insect pathogens. Facilitated by the ease of in vitro culturing, genetic tractability, and availability of relevant infection models, studies of pathogenic Yersinia have revealed a great deal about physiological processes at the molecular level that contribute to pathogen adaptation to the ever changing environments both inside and outside of the host. Comprehensive genome sequencing analyses has further benefitted understanding of this bacterial pathogen evolution. Critically, many of these detailed molecular studies also identified potential targets for the design and development of anti-bacterial therapeutic drugs that could help to fight the ever-increasing problem of resistance to conventional antibiotics. New developments in several of these areas are highlighted in this edition of the Research Topic “The Pathogenic Yersiniae – Advances in the Understanding of Physiology and Virulence, Second Edition”.
Exploring Macrophage Metabolic Adaptations to Bacterial Infection: Pathways and Immune Responses
The plasticity of macrophages depends on the spatial distribution, surrounding cell types, external microenvironment and extrinsic stimuli. This represents not only their capability to rapidly adapt, but also their multifunctionality, such as phagocytosing invading pathogens, antigen-presentation, inflammation, tissue homeostasis and regeneration. Pathogenic bacteria can also quickly adapt to their surroundings, e.g., the extracellular milieu or the intracellular compartments of macrophages. Therefore pathogens exhibit a vast repertoire of bacterial virulence factors that intervene by activating, stalling or altering various macrophage cellular processes. Probably the most complex intracellu...
Regulation of Gene Expression in Enteropathogenic Bacteria, Volume II
Following the success of this Research Topic http://journal.frontiersin.org/ researchtopic/3298/regulation-of-gene-expression-in-enteropathogenic-bacteria, we are happy to launch a second edition of the project. Pathogenic bacteria have evolved numerous strategies to survive in and to attack hosts, which can be reflected by transcriptional and posttranscriptional changes in specific genes especially including those encoding virulence determinants. Regulation of gene expression by regulatory proteins and non-coding RNAs enables the pathogens to adapt their metabolic needs and to coordinately express virulence determinants during different stages of infection.
Bacterial Transcription Factors and the Cell Cycle, 2nd edition
Analogous to the eukaryotic G1, S and M phase of the cell cycle, the bacterial cell cycle can be classified into independent stages. Slowly growing bacterial cells undergo three different stages, B-, C- and D-phase, respectively, while the cell cycle of fast-growing bacteria involves at least two independent cycles: the chromosome replication and the cell division. The oscillation in gene expression regulated by transcription factors, and proteolysis mediated by ClpXP, are closely correlated with progression of the cell cycle. Indeed, it has been shown that DnaA couples DNA replication initiation with the expression of the two oscillating regulators GcrA and CtrA, and the DnaA/GcrA/CtrA regu...
Earthquake Precursors in the Atmosphere and Ionosphere
This book discusses how the increased emanation of radon and other gases from the Earth’s crust in the vicinity of active tectonic faults triggers a chain of physical processes and chemical reactions in the atmospheric boundary layer and the Earth’s ionosphere over an earthquake area several days/hours before strong seismic shocks occur. It presents the two main concepts involved in this mechanism: atmosphere ionization and the global electric circuit. The Lithosphere-Atmosphere-Ionosphere Coupling (LAIC) concept is strongly supported by experimental data showing the atmospheric and ionospheric precursors for major recent earthquakes including 2004 Sumatra; 2008 Sichuan, China; 2011 Toho...
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