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Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond
olymerases are the nucleotidyl transferases that are responsible for synthesizing DNA and RNA. They are crucial for essential cellular processes including cellular and viral genome replication, DNA repair and damage tolerance, and transcription. Consistent with their vital roles, polymerases are found in all domains of life. The overall chemistry employed by these enzymes is conserved but there are variations among the different groups of polymerases that confer different substrate specificities and nucleotide incorporation fidelities that allow them to be involved in a wide array of cellular activities. Since polymerases were first isolated more than six decades ago, we have made great progress in understanding how different polymerases have adapted to their specific roles. In this Research Topic we will focus on the enzymatic mechanisms of these enzymes and the relationships between polymerase structure and mechanism, to highlight common themes and unique adaptations.
International Coordinating Group on vaccine provision for cholera
The annual ICG meeting takes place once a year to review the epidemiological situation of each one of the diseases under the ICG mechanism, to review the outbreaks and campaigns supported by ICG, discuss the vaccine demand in the previous year and supply forecast, discuss production plans of vaccine manufacturers and future vaccine developments, and to decide on the stockpiles size and composition for the next year.
Guided-Wave Optics
This book is a printed edition of the Special Issue "Guided-Wave Optics" that was published in Applied Sciences
Museum and Archive on the Move
The digital revolution fundamentally changed how cultural heritage is created, documented, analyzed, and preserved. The book focuses on this transformation’s impact. How must museums and archives meet the challenges of digitally generated cultures and how does the digital revolution influence traditional object collection, research, and education? How do digital technologies and digital art and culture affect our interaction with images? Leading international experts from various disciplines break new ground. Pioneering interdisciplinary research results collected in this book are relevant to education, curators and archivists in the arts and culture sector and in the digital humanities.
Digital Audio Broadcasting
Digital Audio Broadcasting revised with the latest standards and updates of all new developments The new digital broadcast system family is very different from existing conventional broadcast systems. It is standardised in a large number of documents (from ITU-R, ISO/IEC, ETSI, EBU, and others) which are often difficult to read. This book offers a comprehensive and fully updated overview of Digital Audio Broadcasting (DAB, DAB+) and Digital Multimedia Broadcasting (DMB), and related services and applications. Furthermore, the authors continue to build upon the topics of the previous editions, including audio coding, data services, receiver techniques, frequencies, and many others. There are ...
