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What happens when the immune system turns against its own red blood cells? Discover the science behind Autoimmune Hemolytic Anemia (AIHA) in this comprehensive guide. EXPLAINS THE ROOT CAUSES: Understand how the immune system mistakenly attacks red blood cells, leading to hemolysis. DETAILED CLASSIFICATION OF AIHA SUBTYPES: Learn about Warm AIHA, Cold Agglutinin Disease, and more. SYMPTOMS AND DIAGNOSIS INSIGHTS: Recognize the signs and diagnostic approaches to detect AIHA early. DISCUSSION ON TREATMENT STRATEGIES: Explore medical and supportive treatments to manage this complex condition. EPIDEMIOLOGY AND RISK FACTORS: Gain insight into who is most affected by AIHA and the factors involved. This book is an essential resource for those seeking to understand AIHA, providing a deep dive into its causes, subtypes, and management options. Ideal for healthcare professionals, students, and anyone affected by AIHA, it demystifies this rare autoimmune disorder for better awareness and care.
In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more. - Contains 11 relevant, practice-oriented topics including diagnosis and differential diagnosis; red cell antigens and antibodies; traditional and novel tests; DAT neg AIHA; and more. - Provides in-depth clinical reviews on new developments in the understanding and treatment of autoimmune hemolytic anemia, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
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This is a collection of papers presented at the B Lymphocytes and Autoimmunity conference held on May 21-25, 1996 in Prague. The information presented includes data on B cell subset identification and development, antibody repertoire selection, tolerance induction, and antigen presentation. Each of these has a significant impact on the generation of autoantibodies and the development of autoimmune disease. A multidisciplinary discussion of the basic and clinical aspects of B cell function and autoimmunity is provided.
Hemolytic anemia is a clinical condition where red blood cell (RBC) destruction exceeds the ability of the body to supply new ones. In immunohemolytic anemia, the causes of the destruction are antibodies against RBC antigens. These antibodies may be either alloantibodies (isoantibodies), transfused or transferred across the placenta (e.g., in hemolytic anemia of the newborn), or autoantibodies (in AIHA). Once formed, these antibodies bind to the surface of RBCs, marking them for destruction in the blood vessels (intravascular hemolysis) and/or for elimination by phagocytosis by macrophages in the reticulo-endothelial system (extravascular hemolysis). This book presents current research on the symptoms, diagnosis and treatment of AIHA. Chapter One examines oxidative stress in AIHA. Chapter Two discusses AIHA in primary immunodeficiency disorders, while Chapter Three studies AIHA in cancer disorders. Chapter Four reviews AIHA post solid organ transplants. The final chapter reviews the incidence, possible pathophysiology, clinical presentations, management strategies and challenges and outcome after an allogeneic hematopoietic stem cell transplant.
The landmark emergency medicine text is now in full color 17 additional chapters available for download With 418 contributors representing over 120 medical centers around the world, Tintinalli’s Emergency Medicine is the most practical and clinically rigorous reference of its kind. It covers everything from prehospital care, disaster preparedness, and basic resuscitative techniques, to all the major diseases requiring emergency treatment, such as pulmonary emergencies, renal and GU disorders, and hemophilia. This authoritative, in-depth coverage makes this classic text indispensible not only in emergency departments, but also for residents and practitioners when studying or preparing for a...
The standard reference in occupational health and safety for over 50 years, the new Patty's presents for the first time a separation of industrial hygiene and toxicology topics, offering complete reorganization of the material into four volumes of clearly defined topic areas.
This text reflects the substantial advances that have taken place in the past 30 years in the understanding of the structure of antibodies and of the mechanism and regulation of their formation, as well as the genesis of auto-immune diseases.
Market: oncologists (20,000), hematologists (15,000), oncology fellows (2,500), hematology fellows (2000), internal medicine residents (23,000), internists (75,000), family practice residents and clinicians (55,000), cancer-care nursing (40,000), first and second year medical students (18,000/year)
This is a practical guide for safe and effective use of blood as a drug. It has a practical focus, with a format that blends transfusion science with clinical concerns, and includes contributions from the areas of pathology, internal medicine, surgery, anaesthesiology and paediatrics. This new edition includes 15 new chapters, and the Organization of Blood Services section has been restructured to guide the reader through the intensified regulatory environment and the use of computers a control devices. The text also discusses how blood banks can meet the FDA's tight new guidelines, using audit and error management as the key to process control.