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Ion Channels
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts: Part one - an introductory overview of the ion channel superfamily and the ...
Neuroscience: Exploring the Brain
Neuroscience: Exploring the Brain, Fifth Edition delivers a comprehensive, student-friendly introduction to the structure and function of the nervous system. Updated to reflect the latest research, this edition blends foundational science with engaging, real-world applications, making it ideal for introductory neuroscience or biological psychology courses across a wide range of departments, from psychology to allied health. With an approachable tone, expanded illustrations, and thoughtful pedagogy, this trusted text makes complex topics more accessible, even for students without a strong background in science.The Fifth Edition is distinguished by its clarity, adaptability, and practical rele...
Cortical Development
To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.
Voltage-Sensitive Ion Channels
The goal of this book is to explore the complexity of a microscopic bit of matter that exists in a myriad of copies within our bodies, the voltage-sensitive ion channel. We seek to investigate the way in which these macromolecules make it possible for the long fibers of our nerve and muscle cells to conduct impulses. These integral components of cell membranes are marvels of nature's evolutionary adaptation. To understand them we must probe the boundaries of physics and chemistry. Since function is intimately related to structure, we examine the molecular structure of channels, focusing on physical principles that govern all matter. With the application of genetic methods, our knowledge of i...
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Cell Cycle Control
General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Cell cycle regulators in mammalian systems Cell cycle control in yeast and fungal systems Analysis of cell cycle regulators in oocyte, egg, and embryonic systems, as well as general methods
Macromolecular Crystallography, Part D
Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software
Molecular Design and Modeling
Antibody combining site; Antibody - antigen interactions; Catalytic antibodies and vaccines; Nucleic acids an polysaccharides; Drugs.
