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Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists
Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecul...
Musical Improvisation and Open Forms in the Age of Beethoven
Improvisation was a crucial aspect of musical life in Europe from the late eighteenth century through to the middle of the nineteenth, representing a central moment in both public occasions and the private lives of many artists. Composers dedicated themselves to this practice at length while formulating the musical ideas later found at the core of their published works; improvisation was thus closely linked to composition itself. The full extent of this relation can be inferred from both private documents and reviews of concerts featuring improvisations, while these texts also inform us that composers quite often performed in public as both improvisers and interpreters of pieces written by themselves or others. Improvisations presented in concert were distinguished by a remarkable degree of structural organisation and complexity, demonstrating performers’ consolidated abilities in composition as well as their familiarity with the rules for improvising outlined by theoreticians.
Recent Advances in Alzheimer Research
Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's dise...
Laughter Between Two Revolutions
Tells the forgotten story of post-Rossinian opera buffa, with attention to masterpieces by Donizetti and fascinating comic works by Luigi Ricci, the young Verdi, and other composers.This study represents the first substantial assessment of Italian comic operas composed during the central years of the Risorgimento -- the period during which upheavals, revolutions, and wars ultimately led to the liberation andunification of Italy. Music historians often view the period as one during which serious Romantic opera flourished in Italy while opera buffa inexorably declined. Laughter between Two Revolutions revises this widespread notion by viewing well-known comic masterpieces -- such as Donizetti'...
Changing the Score
This study is the first to explore the significance of aria insertion, the practice that allowed singers to introduce music of their own choice into productions of Italian opera during the nineteenth century. Each chapter investigates this practice from varying perspectives and through the experiences of some of the century's most famous prima donnas.
Music of the past, instruments and imagination
This volume presents the proceedings of the second International Congress organised in Lausanne by the harmoniques Foundation and held in the Spring of 2004. The papers were given by experts on brass and stringed keyboard instruments. The emphasis was on a variety of historical instrument-making traditions and on the history of the revival of the use of early instruments. The contributions not only included detailed discussions regarding the parameters of performance practice and the use of historical instruments but also about the inspiration given by some of the leading revivalists in these fields. In many cases the contributors placed a special focus on the performance of the music of Johann Sebastian Bach.
Requiem
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