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Tertiary lymphoid structures (TLS) in the tumor immune microenvironment
Cancer has become the most common disease worldwide. With their extremely aggressive nature of growth, many cancer types portend dismal 5-year survival rates. Chemotherapy, as the conventional treatment option, is the mainstay of treatment for these malignancies, and while some patients derive remarkable clinical response, ultimately chemoresistance prevails. This resistance highlights the self-renewal of tumor cells and reflects its notorious capacity to mediate a microenvironment that is tumor protective. Recently, immunotherapy achieved great successes in tumors with abundant lymphocytes influx, such as melanoma and lung cancer. But, none of the immunotherapeutic regimens have been effective in immune-privileged cancers, reflecting an immune suppressive microenvironment that is lack of immune cell infiltration along with the tumor initiation, development, and progression, as known as ‘cold’ tumor.
UPAT – Urban Planning Advisory Team
As part of the ISOCARP 50th anniversary programme, the publication of Ten Years of UPATs: Reflections and Results is certainly one of the "flagship" activities of ISOCARP. We have to thank the editors and authors, as well as all the members of the Urban Planning Advisory Teams who contributed to the impressive quality of this publication. The initiation of the UPATs was a turning point in the activities of ISOCARP as a professional organisation. Instead of limiting its role to reflecting on activities, it turned into a pro-active organisation intervening in the real world, rather than serving only as a consultant. The UPATs try to "open eyes and doors", to think and act in other directions, ...
Kiwifruit
Kiwifruit: The Genus ACTINIDIA includes extensive and full coverage of scientific and applied information, ranging from basic taxonomy, population genetics, and natural resources/distribution, to domestication history and breeding/cultivars, also including further information on culture and international production and commercialization. The book gathers information not previously available in the English language, providing an authoritative reference for professionals, including taxonomists, horticulturist, breeders, conservationists, kiwifruit technicians, college teachers, policymakers in the industry, and governments. In addition to those in the academic and professional sectors, horticultural and botanical enthusiasts will find the information presented highly accessible. - Presents the first world monograph on the genus Actinidia (kiwifruit) - Provides up-to-date research based on "everything kiwi, including new and critical information on kiwi germplasm and taxonomy from China, the native country of kiwi - Includes authoritative and detailed descriptions for each species, with extensive color illustrations and information accumulated during the author's 30 years of research
Abiotic stress mechanisms and enhancement in crops: Physiological and biochemical approaches
Changes in natural ecosystems can affect biodiversity on a global scale, which in turn affects global food production. Climate change develops under different environmental conditions such as high CO2 concentration, ultraviolet radiation, temperature, salinity, rainfall intensity, etc., causing an increase in the growth of new weeds and pathogens. All these factors alone and in complex can reduce growth, complicate photosynthesis, and reduce the physiological and biochemical responses of plants. On the other hand, studies in recent years have shown that the development of a dual strategy of breeding for stress tolerance and introducing stress tolerant plants into production systems to increa...
Progress in Materials Science and Engineering: ICMSE 2013
Selected, peer reviewed papers from the 2013 International Conference on Material Science and Engineering (ICMSE2013), October 4-6, 2013, Guilin, Guangxi, China
