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Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Faust has been called the fundamental icon of Western culture, and Goethe's inexhaustible poetic drama is the centrepiece of its tradition in literature, music and art. In recent years, this play has experienced something of a renaissance, with a surge of studies, theatre productions, press coverage and public discussions. Reflecting this renewed interest, leading Goethe scholars in this volume explore the play's striking modernity within its theatrical framework. The chapters present new aspects such as the virtuality of Faust, the music drama, the modernization of evil, Faust's blindness, the gay Mephistopheles, classic beauty and horror as phantasmagoria, and Goethe's anticipation of modern science, economics and ecology. The book contains an illustrated section on Faust in modern performance, with contributions by renowned directors, critics and dramaturges, and a major interview with Peter Stein, director of the uncut 'millennium production' of Expo 2000.
This book explores the use of human-centered service design. Through a variety of case studies and best practices, it highlights ways to systematically improve the provision of healthcare services to different target and age groups in order to understand customer expectations and needs. The book also offers new insights into the dyadic relationship between service provider and customer, each of which has their own set of goals, purposes, and benefits and must cope with a scarcity of resources and opportunities to optimize and design. Written by recognized experts, scholars, and practitioners, this book demonstrates how, where, and when to successfully apply human-centered service design at m...
Proceedings of an international conference held in Magdeburg, Germany, November 3-5, 1996
In this meticulously curated anthology, exploring the dynamic intersections of creativity, design, and innovation within the healthcare landscape, esteemed experts present novel service design solutions. Engaging with pressing challenges, exchanging insights, and unveiling pioneering approaches, contributors navigate the complexities of healthcare delivery with finesse and foresight. With a multidisciplinary lens, this collection serves as a nexus between theory and practice, offering profound reflections and actionable strategies aimed at elevating patient-centered care. Catering to healthcare professionals, scholars, and policymakers alike, this anthology is poised to catalyze substantive change in the healthcare milieu. Whether exploring the integration of state-of-the-art methodologies or reconceptualizing conventional healthcare paradigms, this collection underscores the paramount importance of creativity, design, and innovation in shaping the trajectory of healthcare delivery.
Advocates an organizational science that focuses on advancing a scholarship of positive human organizations, positive relationships and positive modalities of change, which promise to be of world benefit for individuals, organizations and communities. This title aims to advance a 'scholarship of the positive' and 'positive scholarship'.
Managing as Designing explores "the design attitude," a new focus for analysis and decision making for managers that draws on examples of decision making and leadership in architecture, art, and design. Based on a series of conference papers given at the opening of the Peter B. Lewis Building (designed by Frank Gehry) at the Weatherhead School of Management, Case Western Reserve University, the book includes keynote speeches from Frank Gehry and Karl Weick. The premise of this book is that managers should act not only as decision makers, but also as designers. Though decision and design are inextricably linked in management action, managers and scholars have too long emphasized the decision ...
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The first American academic journal to examine design history, theory, and criticism, Design Issues provokes inquiry into the cultural and intellectual issues surrounding design. Regular features include theoretical and critical articles by professional and scholarly contributors, extensive book reviews, illustrations, and a section for reader response. Special issues concentrate on particular themes, such as artificial intelligence, product seminars, design in Asia, and design education.