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Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer
There is an urgent need for the discovery of new drugs against infectious diseases and cancer. Globally, infectious diseases are prevalent, with pathogens constantly evolving, leading to a rise in drug-resistant strains. This necessitates the development of new antimicrobial agents capable of overcoming resistance. Moreover, the COVID-19 pandemic highlighted the critical need for rapid drug development against emerging infectious diseases. Cancer, a leading cause of death worldwide, presents challenges due to its complexity and diversity, and the unique genetic profiles of patients. The American Cancer Society notes increasing cancer rates, underscoring the need for more effective, targeted ...
Drug Metabolism and Pharmacokinetics
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successf...
Evidence Based Validation of Traditional Medicines
The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of tr...
Applications of Functional Foods in Disease Prevention
Functional food sources are growing in popularity because they are exceptionally nutritious and provide amazing medical advantages. They can help ensure against infection, prevent supplement deficiency, and advance appropriate health development and improvement. With illustrative case studies, this new volume explores the many roles of functional foods in the prevention and management of various diseases, including diabetes, autism spectrum disorder, weight loss and obesity, microbial infections, ulcers and other gastrointestinal diseases, mental disorders and brain health, cardiac health and cardiovascular diseases, osteoporosis and bone health, and more.
Indian Systems of Medicine
The book "Indian Systems of Medicine" by Soumya Bhattacharya and Mithun Rudrapal is an exhaustive resource that delves into the principles and practices of Indian Systems of Medicine (ISM). The authors provide a comprehensive introduction to Indian Systems of Medicine (ISM), covering its history, philosophy, and various branches, including Ayurveda, Yoga, Siddha, Unani, and Homoeopathy. The book also explores the integration of Indian Systems of Medicine (ISM) with modern scientific standards and research methodologies, addressing topics such as formulation development, standardization techniques, and Good Manufacturing Practices (GMP) for Indian Systems of Medicine (ISM) formulations. Additionally, it discusses contemporary challenges in quality assurance, safety monitoring, and regulatory frameworks, making it an invaluable resource for students, practitioners, researchers, and academicians.
Nanotechnology in Biology and Medicine
Nanotechnology in biology and medicine: Research advancements & future perspectives is focused to provide an interdisciplinary, integrative overview on the developments made in nanotechnology till date along with the ongoing trends and the future prospects. It presents the basics, fundamental results/current applications and latest achievements on nanobiotechnological researches worldwide scientific era. One of the major goals of this book is to highlight the multifaceted issues on or surrounding of nanotechnology on the basis of case studies, academic and theoretical articles, technology transfer (patents and copyrights), innovation, economics and policy management. Moreover, a large variet...
Drug Repurposing and Computational Drug Discovery
Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates. This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threa...
Dietary Polyphenols in Human Diseases
Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of their diverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest information in the area of polyphenol-based drug discovery research. The book focuses on the current understanding of the beneficial effects on human health of diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) and their possible preventive role in the management of chronic human diseases. In addition...
Computational Methods for Rational Drug Design
Comprehensive resource covering computational tools and techniques for the development of cost-effective drugs to combat diseases, with specific disease examples Computational Methods for Rational Drug Design covers the tools and techniques of drug design with applications to the discovery of small molecule-based therapeutics, detailing methodologies and practical applications and addressing the challenges of techniques like AI/ML and drug design for unknown receptor structures. Divided into 23 chapters, the contributors address various cutting-edge areas of therapeutic importance such as neurodegenerative disorders, cancer, multi-drug resistant bacterial infections, inflammatory diseases, a...
The Biology of Trauma
USA Today Bestseller Publishers Weekly Bestseller This groundbreaking book breaks down the latest research to reveal how trauma impacts our bodies on a cellular level and offers an empowering path to whole-body healing. Today, we know more about mental health than ever before, but traditional medicine still mistakes subtle signs of trauma for stress, anxiety, or chronic disease—sometimes even retraumatizing patients with outdated and misguided methods. Treatment plans that focus on the mind are only addressing the downstream effects. Likewise, common medical approaches to manage symptoms fail to explore root causes and promote genuine recovery. If we want to truly heal, we need to understa...
