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Biology of Longevity and Aging
An introductory text to the biology of aging and longevity, offering a thorough review of the field.
Extending the Lifespan
This book collects the essays and presentations that were the product of a highly successful international meeting on experimental gerontology, conducted by the German Society for Gerontology and Gerontology in September 2003. In this volume, specialists from a variety of backgrounds address a multitude of issues including: Theories of Aging * Analytical Gerontology * Nutrition and Lifespan * Antioxidants * Genetic Repair * Life Extension Mathematics * Tissue Engineering * Transplantation * Stem Cells * Cryopreservation * Nanotechnology * Criminology * Ethics in Research and Care
Genetics and Evolution of Aging
Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Cl...
The Molecular Genetics of Aging
The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, ...
Aging of Organisms
Biological aging as the time-depending general decline of biological systems associated with a progressively increasing mortality risk is a general phenomenom of great significance. The underlying processes are very complex and depending on genetic and environment factors. These factors encode or affect a network of interconnected cellular pathways. In no system this network has been deciphered in greater detail. However, the strategy of studying various biological systems has let to the identification of pathways and specific modules and makes it obvious that aging is the result of different overlapping mechanisms and pathways. Some of these appear to be conserved ("public") among species, ...
Modeling Cooperative Behavior in the Social Sciences
These papers were peer-reviewed. The Granada Seminar is defined as a small topical conference whose pedagogical effort is especially aimed at young researchers. This year's seminar covered the modelling of complex systems that are of interest in the social sciences. In an effort to offer pedagogical notes, each topic is comprehensively described and some practical exercises are proposed. This helps introduce non-experts to novel advances in statistical physics and to the creative use of computers in scientific research, as well as to serve as a work of reference for teachers, students and researchers.
Molecular Aspects of Aging
As we approach the twenty-first century, aging is likely to emerge as a leading issue for biological and biomedical scientists. The elucidation of the underlying mechanisms of aging may constitute the most effective approach to the prevention or postponement of major geriatric disorders. An understanding of why individual subjects vary in their susceptibilities to these disorders will be of special significance to future medicine. To further this understanding, a unique dialogue was initiated between biologists, geneticists, biochemists, pathologists, immunologists, physicians, and other biomedical scientists concerned with the molecular mechanisms of aging, which is reflected in this volume...
Handbook of Physiology
The aims of this new section of the Handbook of Physiology are two. One is to present a source of basic knowledge about aging including research approaches for use by physiologists as well as other biologists not directly involved in aging research. The other is to provide comprehensive information for gerontologists on the physiological characteristics of aging in mammals, particularly humans. The principles of biological gerontology are presented in Part I, which includes discussions of approaches to the measurement of the rate of aging of populations, the difficulty of assessing aging of the individual, theoretical concepts regarding the nature of aging, and conceptual issues concerning t...
