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Vitiligo has been, until recently, a rather neglected area in dermatology and medicine. Patients complain about this situation, which has offered avenues to quacks, and has led to the near orphan status of the disease. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. Vitiligo is still considered by doctors as a non disease, a simple aesthetic problem. A good skin-based angle of attack is also lacking because generalized vi- ligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (d...
Although vitiligo has traditionally been very difficult to treat, a new breakthrough surgical treatment is expanding options for practitioners and patients. Standard treatments depend on the severity of the condition and the patient's feelings of disfigurement. Cover-up cosmetics work well for some people. Other more sophisticated forms of treatment include gradually developing color back in the depigmented areas (repigmentation) by PUVA or other ultraviolet light treatments, but this is extremely slow and intensive, often requiring several hundred treatments. This new form of treatment, which involves surgically transplanting melanocytes into the white areas, is most successful in patients ...
This issue of Dermatologic Clinics, guest edited by John E. Harris, MD, PhD, is devoted to Vitiligo. Articles in this timely issue include: History of Vitiligo Management; Quality of Life/Burden of Disease; Comorbidities/Systemic Effects; Skin Cancer Risk (NMSC/Melanoma); Presentations, Signs of Activity, Differential Diagnosis; Segmental Vitiligo; Chemical-Induced Vitiligo; Medical Therapy and Maintenance of Vitiligo; Phototherapy and Combination Therapies for Vitiligo; Surgical Therapy; Depigmentation Therapy; Special Considerations in Children with Vitiligo; Role of Diet and Supplements in Vitiligo Management; Genetics; Pathogenesis and Emerging Treatments; and Repigmentation/Melanocyte Regeneration in Vitiligo.
Almost nine months since the first recorded case, the novel betacoronovirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now passed 18 million confirmed cases. The multi-disciplinary work of researchers worldwide has provided a far deeper understanding of COVID-19 pathogenesis, clinical treatment and outcomes, lethality, disease-spread dynamics, period of infectivity, containment interventions, as well as providing a wealth of relevant epidemiological data. With 27 vaccines currently undergoing human trials, and countries worldwide continuing to battle case numbers, or prepare for resurgences, the need for efficient, high-quality pipelines for peer-reviewed research remains as crucial as ever.
The skin is colored by a blend of pigments, which form part of a complex and highly regulated process. Pigmentary defects normally present with dyschromia and can be caused by genetic defects, systemic disease, inflammatory processes, metabolic defects, infections, tumors, or toxic or iatrogenic causes. This atlas is an extensive text written by key opinion leaders within dermatology, it has a comprehensive format that guides the reader through the epidemiology, pathophysiology, diagnosis, treatment, and differential diagnosis of both common and rare pigmentary disorders. It illustrates the diagnosis and recognition of pigmentary disorders with a wide range of images.
Savoir comment la création jouerait matériellement et spirituellement du mode mineur est une préoccupation fondatrice de la poïétique. Celle-ci a en effet pour objet l'analyse de l'acte créateur dans tous les domaines et dans tous les registres où les oeuvres s'élaborent. ...
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Recalling Tocqueville's exhortation for the French to "look to America" for a better understanding of their own government, John Rohr returns the favor by revealing how much we can learn about American constitutionalism from a close study of French governance. The French and American republics both emerged from the same revolutionary era and share a common commitment to separation of powers, rule of law, and republicanism. Even so, the two constitutional traditions are quite different. France, after all, has replaced its constitution at least thirteen times since 1789, while the American constitution has endured essentially intact. Yet, as Rohr shows, French constitutionalism merits our care...
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