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Development of Isatin as CNS Agents: Anticonvulsant Activity
The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to reaction with different amines or anilines to form respective sulphonamide derivatives. The new compounds were characterized based on spectral (FT-IR, NMR and Mass) analysis. All the test compounds showed CNS depression while studying the gross behavioral changes. All the test compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed more reduction in the locomotor activity among all the test compounds. Compounds IIId, IIIc, IIIb, IIIa were next in the order of reduction of locomotor activity. The compounds were evaluated for anticonvulsant activity against maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.
Compatible Solutes Engineering for Crop Plants Facing Climate Change
Plants, being sessile and autotrophic in nature, must cope with challenging environmental aberrations and therefore have evolved various responsive or defensive mechanisms including stress sensing mechanisms, antioxidant system, signaling pathways, secondary metabolites biosynthesis, and other defensive pathways among which accumulation of osmolytes or osmo-protectants is an important phenomenon. Osmolytes with organic chemical nature termed as compatible solutes are highly soluble compounds with no net charge at physiological pH and nontoxic at higher concentrations to plant cells. Compatible solutes in plants involve compounds like proline, glycine betaine, polyamines, trehalose, raffinose...
ICT Systems and Sustainability
Dr. Milan Tuba, Professor of Computer Science, Mathematics and Electrical Engineering, Head of the Artificial Intelligence Project at Singidunum University and Vice-Rector of Research at Sinergia University, is included in both versions of the Stanford University list of 2% of the most influential scientists in the world in all disciplines, one for contribution during the entire career and other for contribution in the previous year (for years 2020, 2021, 2022, 2023 and 2024). Prof. Tuba is the highest ranked researcher in Serbia for Computer Science field at AD Scientific Index - World Scientists Rankings. Prof. Tuba is the author or co-author of around 300 scientific papers (cited more tha...
Click, Automate and Save
Powerful strategies that allow you to finish 80% of your office tasks with only 20% of your effort. This book contains many proven Excel solutions from my ten years of experience with Excel, Google Sheets, VBA, and Power Query. It targets executives, analysts, and team members. Zero initiative will get you nowhere, but the right approach with zero attitude will teach you good habits. In today’s fast-paced, data-driven business environment, Microsoft Excel helps professionals manage, analyze, visualize, and automate data. Lack of knowledge about Excel’s advanced techniques and full potential causes many professionals to be inefficient. It solves data cleaning, mathematical operations, sum...
Financial Engineering with Derivatives
In 10 thought-provoking chapters, some of the industry's heavy-hitters share the latest information on a fascinating range of topics, including exotic options, structured notes, derivatives on foreign equities, mortgage-backed securities, and commodities. These financial experts analyze each innovation in detail, providing a theoretical point of view as well as from an applied real-world perspective. Inside, you'll find creative uses of FLEX options; techniques for increasing returns with structured notes; new applications for currency forwards; ways to reengineer cash flows through mortgage derivatives; important lessons learned from recent derivatives-related losses and much more.
Indian Factories & Labour Reports
Primarily reports labor law judgements in the Supreme Court and High Courts of India. Includes related legislation and rules.
Indian Food Packer
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Annual Report
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