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Targeting the Wnt Pathway in Cancer
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
China's Early Mosques
What happens when a monotheistic, foreign religion needs a space in which to worship in China, a civilisation with a building tradition that has been largely unchanged for several millennia? The story of this extraordinary convergence begins in the 7th century and continues under the Chinese rule of Song and Ming, and the non-Chinese rule of the Mongols and Manchus, each with a different political and religious agenda. The author shows that mosques, and ultimately Islam, have survived in China because the Chinese architectural system, though often unchanging, is adaptable: it can accommodate the religious requirements of Buddhism, Daoism, Confucianism, and Islam.
Current Trends in Greek Linguistics
Current Trends in Greek Linguistics is a collection of fifteen papers written by junior researchers of Greek linguistics, aiming to highlight the ongoing linguistic research on Greek. The collected papers present original research from a fresh perspective, and bring to the fore aspects of the Greek language that have not been extensively examined so far. The authors provide a concise overview of their field and address problems in a variety of theoretical frameworks, including cognitive linguistics, formal linguistics, corpus linguistics, variational sociolinguistics and critical discourse analysis. The volume comprises four sections: Aspects of Meaning, Textual and Sociolinguistic Approache...
Audio- and Video-Based Biometric Person Authentication
This book constitutes the refereed proceedings of the 5th International Conference on Audio- and Video-Based Biometric Person Authentication, AVBPA 2005, held in Hilton Rye Town, NY, USA, in July 2005. The 66 revised oral papers and 50 revised poster papers presented were carefully reviewed and selected from numerous submissions. The papers discuss all aspects of biometrics including iris, fingerprint, face, palm print, gait, gesture, speaker, and signature; theoretical and algorithmic issues are dealt with as well as systems issues. The industrial side of biometrics is evident from presentations on smart cards, wireless devices, and architectural and implementation aspects.
Mathematical Reviews
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