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Tightly linked to tissue engineering and regenerative medicine, genetic and cellular therapies have drawn universal attention. Since genetic sequencing is critical for precision medicine, the combination of bioinformatics and therapies is important to conduct prescriptive and predictive analytics based on genetic sequencing data. Bioinformatics and computational approaches have been widely considered for the development of genetic and cellular therapies. Therefore, the current research topic aims to cover recent advances in studies such as functional genomics, proteomics, metabolomics, and bioinformatics that bring in new perspectives on genetic therapies. The central goal of regenerative me...
Life-saving medical and scientific research-based interventions are extending people's lives and saving the lives of people who have suffered from diseases and injuries. This has led to an increased need for the development of technical and medical devices for the prevention, rehabilitation, and treatment of injuries. With the development of computer technology, more and more virtual models of the human body have been developed for biomedical and biomechanical research and application. Reliable virtual body models can efficiently improve injury prediction and rehabilitation, as well as disease diagnosis and treatment. For the past decade, biomechanical virtual human body models have experienced major advancements in terms of development methods, model biofidelity, availability, and applications.
Given that Volume I of the topic Novel Insights into the Pathophysiology of Diabetes-related Complications: Implications for Improved Therapeutic Strategies has been successfully performed last year, and we have received submissions talking about diabetic retinopathy (DR), diabetic neuropathy (DN), type 2 diabetes mellitus (T2DM)-associated periodontitis, diabetic oxidative liver damage, diabetic-related wound healing, etc. We are pleased to announce the launch of Volume II. Diabetes mellitus (DM), as a major health problem, has been highly prevalent across the globe. It is increasingly apparent that not only a cure for the current worldwide diabetes epidemic is required, but also a cure for...
In the 20th century, toxicology developed slowly and relied on live animal experiments for a long time several decades. With the increasing interest in, which was far from the three R principles of animal experiment ethics alternatives to in vivo testing has become more and more important. As an additional aspect, it is to be mentioned that, traditional in vivo experiments in animals sometimes fail to have many uncertainties, making it difficult to accurately predict the toxicological effects of chemicals on humans. Therefore, in vitro toxicity experiments have rapidly developed, using biological macromolecules, cell lines, biological tissues, and organs as targets instead of live animals. A...
Biofabrication for Orthopedics A comprehensive overview of biofabrication techniques for orthopedics and their novel applications With an ever-increasing global population and the rise in the occurrence of orthopedic diseases amongst an aging population, it is essential for technological advances to meet this growing medical need. Orthopedic biofabrication is a cutting-edge field that seeks to produce novel clinical solutions to this mounting problem, through the incorporation of revolutionary technologies that have the potential to not only transform healthcare, but also provide highly automated and personalized patient solutions. With the advances in the discipline, there is a significant ...
Unique resource provides foundation for worldwide prevention, diagnosis, and treatment of orthopaedic fractures Clinical Epidemiology of Orthopaedic Trauma, Third Edition by renowned orthopaedic surgeon and researcher Yingze Zhang and an impressive cadre of contributors expands on the widely acclaimed prior editions. Leveraging an epidemiological database with the distinction of being the largest domestic and foreign sample volume of orthopaedic trauma, this remarkable book expands on the epidemiology of fractures in China, with national incidence rates new to this edition. It offers a wealth of information that will impact treatment planning, future allocation of resources in trauma care, a...