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Mechanisms and Emerging Therapies in Tremor Disorders
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in ...
A Clinical Approach to Neuro-Ophthalmic Disorders
Neuro-ophthalmology is a merged subspecialty of neurology and ophthalmology dealing with complex multisystem diseases presenting with visual manifestations. This book helps the reader in recognizing, approaching, and managing such a patient. It covers the afferent and efferent systems, pupillary disorders, and Radiology of neuro-ophthalmic conditions. It features individual symptomatology with salient points, their management and differential diagnosis. It has case scenarios, key points, and algorithms along with self-assessment MCQ questions. Its simplified, step wise approach will be a useful resource for neurologists, ophthalmologists, physicians, pediatricians, and optometrists. Key Features • Features a simplified and stepwise clinical approach to neuro-ophthalmic disorders. • Includes case studies and clinical pearls along with self-assessment sections. • Covers to the point and crisp analysis of common complaints faced in neuro-ophthalmology. All the royalties of this book are donated to the Poor Patients Cell of PGIMER, Chandigarh.
Models, Mechanisms, and Maturation in Developmental Dystonia
Dystonia, characterized by involuntary over-contractions or co-contractions of muscle groups, is the third most common movement disorder and afflicts an estimated 300-400 million individuals worldwide. Despite the convergence of this group of disorders on a phenotype of abnormal muscle activity, the underlying pathophysiology of dystonia has proven to be wide-ranging, diverse, and difficult to elucidate. This reality is reflected in the clinic, where dystonia often poses great diagnostic and therapeutic challenges. However, major inroads have been made in defining the causes, with mounting efforts rising to meet the demand of developing therapies to treat this group of devastating disorders....
The New Visual Neurosciences
A comprehensive review of contemporary research in the vision sciences, reflecting the rapid advances of recent years. Visual science is the model system for neuroscience, its findings relevant to all other areas. This essential reference to contemporary visual neuroscience covers the extraordinary range of the field today, from molecules and cell assemblies to systems and therapies. It provides a state-of-the art companion to the earlier book The Visual Neurosciences (MIT Press, 2003). This volume covers the dramatic advances made in the last decade, offering new topics, new authors, and new chapters. The New Visual Neurosciences assembles groundbreaking research, written by international a...
Oxford Textbook of Vertigo and Imbalance
Vertigo, dizziness, and imbalance rank amongst the most common presenting symptoms in neurology, otorhinolaryngology, geriatric medicine, and general practice. These symptoms can originate from many different organs and systems, e.g. the inner ear, general medical conditions, and neurological and psychological disorders. The Oxford Textbook of Vertigo and Imbalance, Second Edition provides an up-to-date summary of the scientific basis, clinical diagnosis, and management of disorders that lead to dizziness and poor balance. The Second Edition has been thoroughly revised and all chapters have been fully reviewed and updated since the last edition 10 years ago. This edition features 29 fully up...
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease, Volume 249, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Sequential Bayesian updating, Maps and Sensorimotor Transformations for Eye-Head Gaze Shifts: Role of the Midbrain Superior Colliculus, Modeling Gaze Position-Dependent Opsoclonus, Eye Position-Dependent Opsoclonus in Mild Traumatic Brain Injury, Saccades in Parkinson's disease -- hypometric, slow, and maladaptive, Brainstem Neural Circuits for Fixation and Generation of Saccadic Eye Movements, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Brain Research series - Includes the latest information on mathematical modeling in motor neuroscience
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms, Volume 248, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Mathematical modeling in clinical and basic motor neuroscience, The math of medicine - the computational lessons learned from the human disease, Mathematical models - an extension of the clinician's mind, From differential equation to linear control systems: the study of the VOR, Closed lop and nonlinear systems, State-space equations and learning, Integrators and optimal control, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Brain Research series - Includes the latest information on mathematical modeling in motor neuroscience
Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspectio...
