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GABA signaling in health and disease
GABAergic neurons provide most of the inhibitory drive of adult networks and play major roles in the integrative properties of brain networks. Alterations of GABAergic signals are associated with major neurological disorders and GABA mimetic drugs are widely used as comfort molecules and to treat several brain disorders. Thus, the inhibitory drive is altered in epilepsies, infantile developmentally related disorders but also Parkinson disease, and anoxo-ischemic insults to just name a few. From the developmental stand point, GABAergic neurons mature before principal neurons and provide an important source of early activities and are thus instrumental in activity dependent modulation of the c...
New treatment perspectives in autism spectrum disorders
Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core...
Epilepsy and Neurodevelopmental Diseases
This topic has been realized in collaboration with Dr. Gabriele Ruffolo, Post Doctoral Researcher at the University of Rome (Sapienza) (ORCID ID: 0000-0002-6554-5496).
The History of Neuroscience in Autobiography
(Publisher-supplied data) This book is the second volume of autobiographical essays by distinguished senior neuroscientists it is part of the first collection of neuroscience writing that is primarily autobiographical. As neuroscience is a young discipline, the contributors to this volume are truly pioneers of scientific research on the brain and spinal cord. This collection of fascinating essays should inform and inspire students and working scientists alike. The general reader interested in science may also find the essays absorbing, as they are essentially human stories about commitment and the pursuit of knowledge. The contributors included in this volume are: Lloyd M. Beidler, Arvid Carlsson, Donald R. Griffin, Roger Guillemin, Ray Guillery, Masao Ito. Martin G. Larrabee, Jerome Lettvin, Paul D. MacLean, Brenda Milner, Karl H. Pribram, Eugene Roberts and Gunther Stent.
The First Outstanding 50 Years of “Università Politecnica delle Marche”
The book describes the significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused. It also discusses solutions to improve the wellbeing of human beings. The book covers the main research achievements in the various disciplines of the life sciences, and includes chapters that highlight mechanisms relevant to all aspects of human diseases, the molecular, cellular, and functional basis of therapy, and its translation into the management of people’s health needs. It also describes research on tradition...
Co-Existence and Co-Release of Classical Neurotransmitters
Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that “a single cell releases only one neurotransmitter”. Until recently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons. It is now clear that the “one neuron, one neurotransmitter” postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neural networks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community.
Kainate Receptors
This volume critically examines the functional actions of the kainate‐type glutamate receptors (KARs). Following on from the larger body of work on the NMDA‐ and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions.
Slow Synaptic Responses and Modulation
Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "S...
EEG: The First 100 Years
Authored by leading experts, this book explores the key milestones in the 100-year history of the electroencephalogram (EEG). It provides a detailed account of its origins, global development, clinical applications, and lasting impact on neuroscience. By tracing its evolution, the book underscores the EEG’s enduring relevance. What distinguishes this volume is its dynamic and forward-looking approach. Rather than a traditional historical account, it presents the story of the EEG as an evolving narrative—connecting past discoveries with future possibilities. With advancements in digital technology, machine learning, and artificial intelligence, the EEG remains central to neuroscientific research and a critical diagnostic tool in various medical fields. This book offers valuable insights into the EEG’s contributions to modern neuroscience and its continued influence. It is intended for neurologists, neuroscientists, neuropsychologists, neurophysiologists, EEG technicians, and medical historians, as well as anyone interested in the development of neuroscience and brain research.
