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Canadian Parliamentary Guide 2008
Provides information on both federal and provincial governments, courts, and their elected and appointed members. Provides descriptions of each of the institutions, including brief historical information and biographical sketches of their members and staff. Covers the results of all federal general elections and by-elections from Confederations to the present.
The Pangenome
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, p...
Exile and Return
Many books of the Hebrew Bible were either composed in some form or edited during the Exilic and post-Exilic periods among a community that was to identify itself as returning from Babylonian captivity. At the same time, a dearth of contemporary written evidence from Judah/Yehud and its environs renders any particular understanding of the process within its social, cultural and political context virtually impossible. This has led some to label the period a dark age or black box – as obscure as it is essential for understanding the history of Judaism. In recent years, however, archaeologists and historians have stepped up their effort to look for and study material remains from the period a...
Genie Civil
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Advances in Cancer Research
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including gene expression in inherited breast cancer, multiparameter analyses of cell cycle regulation in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes, treatment of Epstein-Barr virus-associated malignancies with specific T cells, the role of glycogen synthase kinase-3 in cancer, chronic immune activation and inflammation in the pathogenesis of AIDS and cancer, and molecula...
Immunometabolism: Bridging the Gap Between Immunology and Nutrition
It is common ground that all cells require nutrients to develop, differentiate, and maintain their inherent activities. However, the idea that cells can rapidly alter their metabolism to perform specific functions under the pressure of different microenvironments was just brought to the light. These changes are particularly important for immune cells, as they need to respond quickly to opportunistic pathogens or tissue damage and prevent their spread. The field that investigates the interplay between immunology and metabolism is so-called immunometabolism and has supported the hypothesis that all diseases have a metabolic aspect.
